RFC1
Gene Information
- Official Symbol: RFC1
- Official Name: replication factor C subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5981
- UniProt: P35251
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859}.
Pfam Domains GO Terms
Pfam Domains
| RFC1 |
| BRCT |
| AAA |
GO Terms
| DNA clamp unloading |
| DNA clamp unloader activity |
| Elg1 RFC-like complex |
| DNA replication factor C complex |
| DNA clamp loader activity |
| error-free translesion synthesis |
| error-prone translesion synthesis |
| telomere maintenance via telomerase |
| nucleotide-excision repair, DNA gap filling |
| telomere maintenance via semi-conservative replication |
| telomere maintenance via telomere lengthening |
| RNA-dependent DNA biosynthetic process |
| nucleotide-excision repair, DNA incision, 5-to lesion |
| DNA damage response, detection of DNA damage |
| nucleotide-excision repair, DNA incision |
| translesion synthesis |
| nuclear DNA replication |
| enzyme activator activity |
| cell cycle DNA replication |
| DNA synthesis involved in DNA repair |
| postreplication repair |
| transcription-coupled nucleotide-excision repair |
| telomere maintenance |
| telomere organization |
| double-stranded DNA binding |
| DNA biosynthetic process |
| nucleotide-excision repair |
| DNA-dependent DNA replication |
| DNA replication |
| protein domain specific binding |
| nucleic acid phosphodiester bond hydrolysis |
| anatomical structure homeostasis |
| sequence-specific DNA binding |
| DNA repair |
| detection of stimulus |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| cellular homeostasis |
| cell cycle process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PSMA6 | 0.543 |
| LRR1 | 0.506 |
| PSMD11 | 0.504 |
| CCNA2 | 0.485 |
| ZNF830 | 0.483 |
| PSMA7 | 0.473 |
| DDTL | 0.473 |
| CDT1 | 0.47 |
| EXOSC4 | 0.47 |
| HIST1H2BE | 0.466 |
| MT1E | 0.46 |
| TBC1D3H | 0.454 |
| SLC6A17 | 0.449 |
| CHD4 | 0.448 |
| RPL8 | 0.445 |
| CDC73 | 0.441 |
| C2orf27B | 0.439 |
| RPS12 | 0.439 |
| PSMD14 | 0.437 |
| TOP1MT | 0.436 |
| TBC1D3F | 0.434 |
| POLR1A | 0.432 |
| TBC1D3G | 0.432 |
| PRPF8 | 0.431 |
| KCTD17 | 0.431 |
| TCEB3CL2 | 0.429 |
| CHAF1A | 0.428 |
| PAN2 | 0.426 |
| VASN | 0.426 |
| DHX38 | 0.425 |
| NUP160 | 0.424 |
| TCEB3C | 0.424 |
| PSMB4 | 0.423 |
| NAPA | 0.42 |
| AHCTF1 | 0.419 |
| UTP3 | 0.417 |
| BCL2L1 | 0.417 |
| TSG101 | 0.416 |
| GOLGA6L1 | 0.413 |
| COPG1 | 0.412 |
| TCEB3CL | 0.408 |
| PSMD13 | 0.407 |
| RPS28 | 0.407 |
| SMG5 | 0.406 |
| COPB1 | 0.405 |
| XYLT2 | 0.404 |
| PSMC1 | 0.401 |
| PSMD2 | 0.4 |
| ZFAND5 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 421
- Expression level (log2 read counts): 7.4
Expression Distribution
RFC1 Expression in NALM6 Cells: 7.4
