RPN1

Entrez Summary: N/A
UniProt Summary: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. {ECO:0000250|UniProtKB:E2RQ08, ECO:0000250|UniProtKB:Q9GMB0, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 669/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	25/28
bone	24/26
breast	26/33
central nervous system	49/56
cervix	4/4
colorectal	16/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	64/75
lymphocyte	14/16
ovary	24/26
pancreas	23/24
peripheral nervous system	11/16
plasma cell	15/15
prostate	1/1
skin	19/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	5/5

Expression Distribution

Screen	Score
THZ1 0.06μM R08 exp531	2.1
SNS-032 15μM R08 exp443	2.13

dolichyl-diphosphooligosaccharide-protein glycotransferase activity
oligosaccharyltransferase complex
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
rough endoplasmic reticulum
protein N-linked glycosylation
melanosome
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
peptidyl-amino acid modification
endoplasmic reticulum membrane
endoplasmic reticulum
carbohydrate derivative metabolic process
RNA binding
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane