SF3A2

Entrez Summary: N/A
UniProt Summary: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mdivi-1 15μM R05 exp217	1.74
Nutlin-3A 1.6μM R06 exp294	1.75
Quercetin 20μM R08 exp517	1.76
THZ531 0.225μM R08 exp444	1.78
Vinorelbine 0.001μM R05 exp249	1.8
CB-839 10μM R05 exp224	1.82
Lead acetate 2000μM R08 exp498 no dilution day6	1.82
Lead acetate 2000μM R08 exp497	1.84
Trametinib 10μM R02 exp83	1.86
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.96
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.98
B02 10μM R08 exp453	1.99
Wortmannin 5μM R00 exp38	2.02
Benzoate 10000μM R08 exp455	2.14
Citral 50μM R06 exp274	2.14
Etoposide 0.1μM R05 exp198	2.25
CCCP 1μM R00 exp11	2.34

Global Fraction of Cell Lines Where Essential: 734/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	19/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

U2-type prespliceosome assembly
mRNA 3-splice site recognition
U2-type prespliceosome
U2 snRNP
mRNA splice site selection
U2-type precatalytic spliceosome
spliceosomal complex assembly
catalytic step 2 spliceosome
spliceosomal complex
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
positive regulation of neuron projection development
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
positive regulation of neuron differentiation
positive regulation of cell projection organization
RNA splicing
nuclear speck
ribonucleoprotein complex biogenesis
positive regulation of neurogenesis
mRNA processing
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
mRNA metabolic process
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
zinc ion binding
cellular protein-containing complex assembly
RNA processing
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
positive regulation of cellular component organization
positive regulation of developmental process
RNA binding
generation of neurons