UTP20
Gene Information
- Official Symbol: UTP20
- Official Name: UTP20 small subunit processome component
- Aliases and Previous Symbols: N/A
- Entrez ID: 27340
- UniProt: O75691
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821}.
Pfam Domains GO Terms
Pfam Domains
| DRIM |
GO Terms
| rRNA 5-end processing |
| endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| 90S preribosome |
| endonucleolytic cleavage involved in rRNA processing |
| endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| preribosome, small subunit precursor |
| ncRNA 5-end processing |
| RNA 5-end processing |
| cleavage involved in rRNA processing |
| maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| maturation of 5.8S rRNA |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| small-subunit processome |
| maturation of SSU-rRNA |
| ribosomal small subunit biogenesis |
| RNA phosphodiester bond hydrolysis, endonucleolytic |
| RNA phosphodiester bond hydrolysis |
| rRNA processing |
| rRNA metabolic process |
| nucleic acid phosphodiester bond hydrolysis |
| ribosome biogenesis |
| ncRNA processing |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| negative regulation of cell population proliferation |
| nucleolus |
| RNA processing |
| RNA binding |
| regulation of cell population proliferation |
| RNA metabolic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PSMB2 | 0.534 |
| RPL35 | 0.522 |
| CDC45 | 0.514 |
| TCEB3CL2 | 0.502 |
| PSMA6 | 0.496 |
| EXOSC9 | 0.478 |
| TCEB3C | 0.476 |
| WDR75 | 0.473 |
| TCEB3CL | 0.472 |
| RPS28 | 0.465 |
| SUPT5H | 0.464 |
| DIMT1 | 0.463 |
| RBBP5 | 0.462 |
| RPS12 | 0.462 |
| RPS5 | 0.461 |
| HEATR1 | 0.458 |
| TWISTNB | 0.458 |
| TBC1D3H | 0.457 |
| PRIM1 | 0.452 |
| CBWD5 | 0.452 |
| DTL | 0.45 |
| PSMB4 | 0.45 |
| SF3A3 | 0.448 |
| LRR1 | 0.444 |
| VASN | 0.444 |
| RPS2 | 0.443 |
| FAM160A1 | 0.442 |
| AKIRIN2 | 0.442 |
| RRP7A | 0.442 |
| OGFR | 0.441 |
| CBWD3 | 0.441 |
| TBC1D3C | 0.439 |
| SNIP1 | 0.437 |
| PSMD1 | 0.437 |
| EBNA1BP2 | 0.436 |
| TFIP11 | 0.436 |
| PSMA7 | 0.435 |
| TBC1D3F | 0.435 |
| NPIPB5 | 0.431 |
| TYMS | 0.431 |
| RPS7 | 0.43 |
| TBC1D3G | 0.427 |
| FBXW9 | 0.427 |
| PSMD11 | 0.426 |
| NOL12 | 0.426 |
| CBWD6 | 0.426 |
| AATF | 0.426 |
| CCNA2 | 0.426 |
| ARHGEF35 | 0.425 |
| C14orf93 | 0.423 |
| BYSL | 0.423 |
| POLR2H | 0.422 |
| GOLGA6L4 | 0.422 |
| UTP3 | 0.422 |
| GOLGA6L3 | 0.422 |
| ISCU | 0.421 |
| COPG1 | 0.419 |
| NOL10 | 0.418 |
| TRAPPC8 | 0.418 |
| GOLGA8J | 0.418 |
| POLE | 0.418 |
| VPS28 | 0.417 |
| COPZ1 | 0.415 |
| ATP6AP1 | 0.414 |
| MCOLN1 | 0.414 |
| POLR2J3 | 0.414 |
| TBC1D3 | 0.414 |
| DOCK6 | 0.414 |
| POLR2D | 0.413 |
| COPE | 0.411 |
| MYO1H | 0.411 |
| LOC643669 | 0.41 |
| RPS11 | 0.41 |
| OR10G3 | 0.409 |
| RRP9 | 0.409 |
| RIOK2 | 0.409 |
| PSMB1 | 0.406 |
| CHCHD3 | 0.406 |
| SUPT6H | 0.406 |
| TIMELESS | 0.405 |
| CMYA5 | 0.403 |
| POLA2 | 0.403 |
| MED17 | 0.402 |
| UBL5 | 0.401 |
| TBC1D3E | 0.4 |
| TBC1D3L | 0.4 |
| RPL37A | 0.4 |
| TBC1D3I | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 720/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 24/28 |
| blood | 27/28 |
| bone | 25/26 |
| breast | 32/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 341
- Expression level (log2 read counts): 6.68
Expression Distribution
UTP20 Expression in NALM6 Cells: 6.68
