BVD-523 15μM R02 exp67
Mechanism of Action
Inhibits ERK1/2, ATP-competitive
- Class / Subclass 1: Signal Transduction / Kinase Inhibitor
Technical Notes
Protein References
- PubChem Name: Ulixertinib
- Synonyms: BVD-523; VRT752271
- CAS #: 869886-67-9
- PubChem CID: 11719003
- IUPAC: N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-[5-chloro-2-(propan-2-ylamino)pyridin-4-yl]-1H-pyrrole-2-carboxamide
- INCHI Name: InChI=1S/C21H22Cl2N4O2/c1-12(2)26-20-8-16(17(23)10-25-20)14-7-18(24-9-14)21(29)27-19(11-28)13-4-3-5-15(22)6-13/h3-10,12,19,24,28H,11H2,1-2H3,(H,25,26)(H,27,29)/t19-/m1/s1
- INCHI Key: KSERXGMCDHOLSS-LJQANCHMSA-N
- Molecular Weight: 433.3
- Canonical SMILES: CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)Cl
- Isomeric SMILES: CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)Cl
- Molecular Formula: C21H22Cl2N4O2
Protein Supplier
- Supplier Name: Selleck Chemicals
- Catalog #: S7854
- Lot #: S785401
Protein Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H22Cl2N4O2 433.11926; found 433.1203
Dose Response Curve
- Platform ID: BVD-523
- Min: -21.4275; Max: 66.0260
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 17.1654 |
| IC30 | 17.9440 |
| IC40 | 18.6085 |
| IC50 | 19.2400 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 02
- Dose: 15µM
- Days of incubation: 8
- Doublings: 1.0
- Numbers of reads: 12552010
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 33/19 | Scores |
BVD-523 15μM R02 exp67
BVD-523 15μM R02 exp67 vs Mdivi-1 15μM R05 exp217
BVD-523 15μM R02 exp67 vs RO-3307 4.7μM R02 exp80
BVD-523 15μM R02 exp67 vs UMK57 1μM R01 exp59
BVD-523 15μM R02 exp67 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
BVD-523 15μM R02 exp67 vs Milciclib 2μM R08 exp502
BVD-523 15μM R02 exp67 vs LY2090314 0.003μM R08 exp500 no dilution day6
BVD-523 15μM R02 exp67 vs Bisphenol A 100μM R06 exp269
BVD-523 15μM R02 exp67 vs Cannabidiol 20μM R08 exp466
BVD-523 15μM R02 exp67 vs JQ1 0.8μM R08 exp435
BVD-523 15μM R02 exp67 vs WYE-354 6μM R02 exp90
BVD-523 15μM R02 exp67 vs Dorsomorphin 5μM R07 exp357
BVD-523 15μM R02 exp67 vs UM131593 0.2μM R03 exp106
BVD-523 15μM R02 exp67 vs UM0129480 7μM R02 exp85
BVD-523 15μM R02 exp67 vs PU-H71 1μM R08 exp515
BVD-523 15μM R02 exp67 vs Cerivastatin 0.15μM R05 exp226
BVD-523 15μM R02 exp67 vs Quercetin 20μM R08 exp517
BVD-523 15μM R02 exp67 vs Centrinone 0.5μM R07 exp343
BVD-523 15μM R02 exp67 vs CB-839 10μM R05 exp224
BVD-523 15μM R02 exp67 vs CB-5083 0.4μM R08 exp468
BVD-523 15μM R02 exp67 vs Cryptotanshinone 12μM R05 exp227
BVD-523 15μM R02 exp67 vs LY2090314 0.003μM R08 exp499
BVD-523 15μM R02 exp67 vs Fluvastatin 2.2μM R06 exp282
BVD-523 15μM R02 exp67 vs Nutlin-3A 1.6μM R06 exp294
BVD-523 15μM R02 exp67 vs Docosahexaenoic-acid 50μM R07 exp356
BVD-523 15μM R02 exp67 vs Nicotine 3000μM R08 exp510
BVD-523 15μM R02 exp67 vs Pimelic-diphenylamide-106 5μM R00 exp28
BVD-523 15μM R02 exp67 vs FK-506 30μM R07 exp359
BVD-523 15μM R02 exp67 vs Pterostilbene 16μM R02 exp78
BVD-523 15μM R02 exp67 vs Ibrutinib 10μM R08 exp442
BML-284 0.09μM R08 exp460 vs BVD-523 15μM R02 exp67
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 vs BVD-523 15μM R02 exp67
Aphidicolin 0.4μM R08 exp440 vs BVD-523 15μM R02 exp67
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311 vs BVD-523 15μM R02 exp67
