KIF3C
Gene Information
- Official Symbol: KIF3C
- Official Name: kinesin family member 3C
- Aliases and Previous Symbols: N/A
- Entrez ID: 3797
- UniProt: O14782
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Microtubule-based anterograde translocator for membranous organelles. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Kinesin |
GO Terms
| intraciliary transport involved in cilium assembly |
| motor activity |
| ciliary tip |
| intraciliary transport |
| kinesin complex |
| protein transport along microtubule |
| microtubule motor activity |
| microtubule-based protein transport |
| organelle transport along microtubule |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| transport along microtubule |
| cytoskeleton-dependent intracellular transport |
| antigen processing and presentation of exogenous peptide antigen |
| microtubule-based transport |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| cilium |
| antigen processing and presentation |
| ATPase activity |
| microtubule binding |
| protein-containing complex localization |
| microtubule-based movement |
| microtubule |
| cilium assembly |
| establishment of organelle localization |
| cilium organization |
| Golgi vesicle transport |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| organelle localization |
| microtubule-based process |
| organelle assembly |
| intracellular protein transport |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| ATP binding |
| protein transport |
| intracellular transport |
| peptide transport |
| movement of cell or subcellular component |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| establishment of localization in cell |
| nitrogen compound transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SGC2096 2.6μM R03 exp153 | 1.79 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| POLR2J3 | 0.56 |
| DISP2 | 0.508 |
| TCEB3CL2 | 0.503 |
| RPS12 | 0.498 |
| HGC6.3 | 0.497 |
| PSMC1 | 0.49 |
| VASN | 0.49 |
| COPG1 | 0.49 |
| TBC1D3H | 0.49 |
| OGFR | 0.487 |
| NUP133 | 0.481 |
| POLA1 | 0.481 |
| SF3A1 | 0.481 |
| NPIPB5 | 0.476 |
| MYT1L | 0.473 |
| TCEB3C | 0.471 |
| C14orf93 | 0.471 |
| HIVEP3 | 0.469 |
| TBC1D3G | 0.468 |
| CHD4 | 0.464 |
| TBC1D3L | 0.463 |
| TBC1D3I | 0.462 |
| IGFN1 | 0.462 |
| TBC1D3E | 0.462 |
| TBC1D3K | 0.462 |
| SNIP1 | 0.461 |
| NAPA | 0.458 |
| SLC4A1 | 0.458 |
| RPS2 | 0.456 |
| TCEB3CL | 0.455 |
| CBWD3 | 0.452 |
| CBWD5 | 0.452 |
| ZNF106 | 0.45 |
| HIST2H2BF | 0.449 |
| TBC1D3C | 0.449 |
| FAM160A1 | 0.448 |
| RPS28 | 0.447 |
| MED29 | 0.447 |
| DDTL | 0.447 |
| PSMD3 | 0.447 |
| PSMC2 | 0.445 |
| TFIP11 | 0.444 |
| TBC1D3F | 0.443 |
| PWP2 | 0.443 |
| AAMP | 0.442 |
| COPE | 0.441 |
| UPF1 | 0.441 |
| MYB | 0.44 |
| PSMC6 | 0.438 |
| ORC1 | 0.438 |
| KCTD17 | 0.437 |
| SEC13 | 0.436 |
| DNM2 | 0.436 |
| TBC1D3 | 0.434 |
| RRP7A | 0.433 |
| NARFL | 0.433 |
| C1QTNF9B | 0.432 |
| LIPE | 0.431 |
| AKT1S1 | 0.43 |
| PSMB4 | 0.429 |
| MYO1H | 0.429 |
| EXOSC6 | 0.429 |
| MYLK3 | 0.426 |
| RANBP2 | 0.425 |
| COPA | 0.425 |
| POLR2D | 0.424 |
| SPRR2B | 0.424 |
| SUPT5H | 0.423 |
| RBBP5 | 0.423 |
| CCNA2 | 0.422 |
| VPS54 | 0.422 |
| CWC22 | 0.422 |
| PSMD11 | 0.421 |
| PSMD7 | 0.419 |
| HNRNPA1 | 0.419 |
| RPS19 | 0.418 |
| GOLGA8O | 0.418 |
| PRSS8 | 0.418 |
| CHAF1A | 0.417 |
| AKIRIN2 | 0.416 |
| HIST2H3A | 0.416 |
| HIST2H3C | 0.415 |
| DTL | 0.415 |
| GAR1 | 0.414 |
| ISCU | 0.413 |
| RPS5 | 0.413 |
| TPX2 | 0.413 |
| EGR2 | 0.412 |
| RBM39 | 0.412 |
| NOL10 | 0.411 |
| EXOSC5 | 0.411 |
| NSF | 0.41 |
| FAM25B | 0.41 |
| NUPL1 | 0.408 |
| ATP1A3 | 0.408 |
| TP53TG3B | 0.407 |
| RPL30 | 0.407 |
| TP53TG3 | 0.407 |
| EXOSC4 | 0.407 |
| SAP30BP | 0.407 |
| ANKLE1 | 0.406 |
| TP53TG3C | 0.406 |
| RPSA | 0.405 |
| CDH24 | 0.405 |
| BRD4 | 0.405 |
| RNF4 | 0.405 |
| CCDC64B | 0.404 |
| MED12 | 0.404 |
| SPRR2A | 0.404 |
| ACSF2 | 0.404 |
| SLC5A5 | 0.404 |
| RPS19BP1 | 0.403 |
| SF3B3 | 0.402 |
| SYT9 | 0.402 |
| CBWD6 | 0.401 |
| PAN3 | 0.401 |
| RPS20 | 0.401 |
| S1PR4 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2171
- Expression level (log2 read counts): 4.14
Expression Distribution
KIF3C Expression in NALM6 Cells: 4.14
