ALG14
Gene Information
- Official Symbol: ALG14
- Official Name: ALG14 UDP-N-acetylglucosaminyltransferase subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 199857
- UniProt: Q96F25
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
- UniProt Summary: May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. {ECO:0000269|PubMed:16100110}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1554
- Expression level (log2 read counts): 5.03
ALG14 Expression in NALM6 Cells: 5.03
