NUP205
Gene Information
- Official Symbol: NUP205
- Official Name: nucleoporin 205
- Aliases and Previous Symbols: N/A
- Entrez ID: 23165
- UniProt: Q92621
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016].
- UniProt Summary: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC. {ECO:0000269|PubMed:15229283}.
Pfam Domains GO Terms
Pfam Domains
| DUF3414 |
GO Terms
| nuclear pore inner ring |
| nuclear pore complex assembly |
| nuclear pore organization |
| nuclear periphery |
| pore complex assembly |
| structural constituent of nuclear pore |
| tRNA-containing ribonucleoprotein complex export from nucleus |
| tRNA export from nucleus |
| tRNA transport |
| ncRNA export from nucleus |
| intracellular transport of virus |
| host cell |
| transport of virus |
| protein sumoylation |
| multi-organism localization |
| multi-organism transport |
| nuclear pore |
| regulation of cellular response to heat |
| regulation of glycolytic process |
| regulation of gene silencing by miRNA |
| regulation of carbohydrate catabolic process |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| mRNA export from nucleus |
| viral transcription |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| viral gene expression |
| regulation of gene silencing |
| nucleus organization |
| protein export from nucleus |
| mRNA transport |
| regulation of generation of precursor metabolites and energy |
| nuclear export |
| nuclear envelope |
| RNA transport |
| nucleic acid transport |
| establishment of RNA localization |
| viral life cycle |
| regulation of carbohydrate metabolic process |
| RNA localization |
| nuclear membrane |
| nucleobase-containing compound transport |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| peptidyl-lysine modification |
| regulation of small molecule metabolic process |
| viral process |
| regulation of cellular response to stress |
| protein modification by small protein conjugation |
| symbiotic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| peptidyl-amino acid modification |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| intracellular protein transport |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| SUPT6H | 0.525 |
| PAN3 | 0.488 |
| ORC1 | 0.483 |
| VASN | 0.482 |
| GOLGA6L6 | 0.476 |
| CHD4 | 0.474 |
| LRR1 | 0.473 |
| TCEB3C | 0.468 |
| PSMC6 | 0.468 |
| NUPL1 | 0.465 |
| C1QTNF9B | 0.458 |
| POLA1 | 0.454 |
| TCEB3CL2 | 0.454 |
| TBC1D3C | 0.451 |
| LAD1 | 0.45 |
| C14orf93 | 0.449 |
| EXOSC5 | 0.447 |
| PAN2 | 0.446 |
| TBC1D3G | 0.445 |
| RPSA | 0.445 |
| CBWD3 | 0.443 |
| DDTL | 0.443 |
| TP53TG3 | 0.442 |
| TP53TG3B | 0.442 |
| PCF11 | 0.442 |
| TP53TG3C | 0.441 |
| UPF1 | 0.44 |
| ATP6V0C | 0.438 |
| DNTTIP2 | 0.437 |
| PAF1 | 0.436 |
| CLPX | 0.436 |
| NUP160 | 0.436 |
| NUP155 | 0.435 |
| SUPT5H | 0.434 |
| PIGS | 0.432 |
| POLE | 0.431 |
| OSBP | 0.43 |
| CDCA3 | 0.43 |
| TCEB3CL | 0.43 |
| MED14 | 0.429 |
| ANKLE2 | 0.426 |
| ARCN1 | 0.426 |
| SLC6A17 | 0.425 |
| PSMB4 | 0.423 |
| MT1E | 0.423 |
| HAP1 | 0.422 |
| ISCU | 0.422 |
| DDX21 | 0.421 |
| DISP2 | 0.42 |
| RAD51 | 0.419 |
| CCNA2 | 0.418 |
| KRT78 | 0.417 |
| RAD21 | 0.416 |
| COPB1 | 0.416 |
| SF3A1 | 0.416 |
| AKIRIN2 | 0.415 |
| CBWD5 | 0.415 |
| COPE | 0.415 |
| MFSD12 | 0.415 |
| TBC1D3H | 0.414 |
| HIST2H2BF | 0.413 |
| DHFR | 0.412 |
| ZFAND5 | 0.412 |
| RUVBL2 | 0.411 |
| OGFR | 0.411 |
| MDM2 | 0.41 |
| RPL35 | 0.41 |
| NBPF10 | 0.409 |
| DTL | 0.408 |
| RPL14 | 0.407 |
| HIST1H2BE | 0.405 |
| PSMA6 | 0.405 |
| GOLGA6A | 0.403 |
| NBPF16 | 0.403 |
| TFIP11 | 0.402 |
| TBC1D3L | 0.401 |
| TBC1D3K | 0.4 |
| SNRPA1 | 0.4 |
| CKAP5 | 0.4 |
| TBC1D3E | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 613/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 25/28 |
| blood | 26/28 |
| bone | 19/26 |
| breast | 25/33 |
| central nervous system | 48/56 |
| cervix | 0/4 |
| colorectal | 15/17 |
| esophagus | 11/13 |
| fibroblast | 1/1 |
| gastric | 13/16 |
| kidney | 13/21 |
| liver | 18/20 |
| lung | 62/75 |
| lymphocyte | 15/16 |
| ovary | 23/26 |
| pancreas | 21/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 11/15 |
| prostate | 1/1 |
| skin | 16/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 18/22 |
| urinary tract | 22/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 981
- Expression level (log2 read counts): 8.4
Expression Distribution
NUP205 Expression in NALM6 Cells: 8.4
