OSBP

Entrez Summary: N/A
UniProt Summary: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
WYE-354 6μM R02 exp90	-2.96
BH1 1μM R04 exp169	-2.84
Oligomycin-A 20μM R00 exp26	-2.75
Pimelic-diphenylamide-106 5μM R00 exp28	-2.62
Bleomycin 5μM R08 exp459	-2.5
PU-H71 1μM R08 exp515	-2.31
Etoposide 1μM R00 exp19	-2.3
Etoposide 0.3μM R05 exp199	-2.28
Actinomycin-D 0.001μM R00 exp3	-2.25
Bortezomib 0.05μM R00 exp7	-1.98
Brefeldin A 0.02μM R00 exp8	-1.97
GSK461364A 0.1μM R03 exp126	-1.95
BI-6727 0.04μM R03 exp98	-1.89
Bafilomycin-A1 0.009μM R08 exp454	-1.87
Rotenone 20μM R00 exp34	-1.8
Atovaquone 15μM R08 exp451	-1.75
Monensin 0.3μM R08 exp507	-1.73
Nicotinamide 1000μM R03 exp101	1.71
UM0011500 5μM R05 exp245	1.73
BRD2 inhibitor II 20μM R07 exp341	1.81
Pifithrin-alpha 20μM R07 exp390	1.87
Heregulin-B 44ng/ml R08 exp486	1.91
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.95

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution