RPS3A
Gene Information
- Official Symbol: RPS3A
- Official Name: ribosomal protein S3A
- Aliases and Previous Symbols: N/A
- Entrez ID: 6189
- UniProt: P61247
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role during erythropoiesis through regulation of transcription factor DDIT3. {ECO:0000255|HAMAP-Rule:MF_03122}.
Pfam Domains GO Terms
Pfam Domains
| Ribosomal S3Ae |
GO Terms
| mRNA 5-UTR binding |
| cytosolic small ribosomal subunit |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| ribonucleoprotein complex |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| RNA catabolic process |
| establishment of protein localization to membrane |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| protein localization to membrane |
| organic cyclic compound catabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| nucleolus |
| negative regulation of apoptotic process |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| negative regulation of cell death |
| intracellular protein transport |
| endoplasmic reticulum |
| macromolecule catabolic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RPS5 | 0.55 |
| RPS9 | 0.548 |
| RPS3 | 0.545 |
| DDX56 | 0.537 |
| RPS12 | 0.521 |
| RPS16 | 0.519 |
| CDC6 | 0.51 |
| RPS7 | 0.502 |
| NOL10 | 0.501 |
| VASN | 0.499 |
| PRIM1 | 0.493 |
| NOB1 | 0.486 |
| RPL35 | 0.485 |
| POLA2 | 0.485 |
| GOLGA8O | 0.484 |
| BYSL | 0.483 |
| PSMB4 | 0.481 |
| TFIP11 | 0.481 |
| ADRM1 | 0.478 |
| RPL9 | 0.477 |
| RPS2 | 0.475 |
| RPS19 | 0.472 |
| UTP6 | 0.472 |
| TCEB3C | 0.47 |
| ORC6 | 0.466 |
| PSMD3 | 0.461 |
| C14orf93 | 0.461 |
| TCEB3CL2 | 0.458 |
| MDM2 | 0.457 |
| RPL14 | 0.457 |
| SUPT6H | 0.457 |
| RPS11 | 0.456 |
| RPS14 | 0.454 |
| PSMA7 | 0.453 |
| PLK4 | 0.453 |
| NOP16 | 0.453 |
| TWISTNB | 0.452 |
| LRR1 | 0.449 |
| CDC73 | 0.449 |
| CKAP5 | 0.448 |
| TSPY8 | 0.443 |
| COPE | 0.442 |
| PSMD11 | 0.439 |
| DTL | 0.439 |
| TERF2 | 0.438 |
| MYO1H | 0.437 |
| TCEB3CL | 0.437 |
| NBPF10 | 0.436 |
| CDK8 | 0.436 |
| MPHOSPH10 | 0.436 |
| KCTD17 | 0.435 |
| PSMA6 | 0.434 |
| GOLGA6B | 0.433 |
| PSMB1 | 0.433 |
| RNF113A | 0.431 |
| RPL6 | 0.431 |
| EBNA1BP2 | 0.43 |
| TBC1D3 | 0.428 |
| CDC45 | 0.426 |
| PCF11 | 0.424 |
| KRT78 | 0.423 |
| TICRR | 0.422 |
| PLA2G4F | 0.42 |
| CBWD3 | 0.42 |
| RPS28 | 0.42 |
| SF3A3 | 0.419 |
| TBC1D3G | 0.419 |
| NIP7 | 0.419 |
| ORC1 | 0.418 |
| NPIPB5 | 0.418 |
| GOLGA6A | 0.418 |
| NOC4L | 0.416 |
| TBC1D3F | 0.416 |
| CCNA2 | 0.415 |
| WDR43 | 0.415 |
| PSMB2 | 0.415 |
| GOLGA6L1 | 0.413 |
| TBC1D3C | 0.411 |
| KIAA0947 | 0.411 |
| SLC6A17 | 0.41 |
| ACSF2 | 0.41 |
| CBWD5 | 0.41 |
| YY1 | 0.409 |
| EIF4A3 | 0.409 |
| SUPT5H | 0.409 |
| CHD4 | 0.409 |
| TAF1 | 0.409 |
| TBC1D3H | 0.405 |
| CDCA3 | 0.403 |
| NOL12 | 0.403 |
| PSMC5 | 0.403 |
| DISP2 | 0.402 |
| GOLGA6L3 | 0.402 |
| TBC1D3K | 0.401 |
| TBC1D3L | 0.401 |
| TBC1D3E | 0.401 |
| TBC1D3I | 0.401 |
| CLCN6 | 0.4 |
| SNRPA1 | 0.4 |
| CTAGE4 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 716/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 27/28 |
| blood | 27/28 |
| bone | 25/26 |
| breast | 30/33 |
| central nervous system | 54/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 71/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 28/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 231
- Expression level (log2 read counts): 9.8
Expression Distribution
RPS3A Expression in NALM6 Cells: 9.8
