WDR75

Entrez Summary: N/A
UniProt Summary: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 20μM R00 exp34	-2.33
MLN-4924 2μM R00 exp22	-2.13
Rotenone 2μM R00 exp33	-1.82
Etoposide 0.3μM R05 exp199	-1.76
Hinokiflavone 12μM R08 exp487	-1.75
Staurosporine 0.02μM R08 exp524	-1.75
Asunaprenir 3μM R07 exp336	1.7
Epothilone-B 0.0015μM R05 exp231	1.7
RS-1 10μM R08 exp519	1.72
CB-839 10μM R05 exp224	1.74
UM0131023 0.05μM R05 exp248	1.78
MKC9989 10μM R03 exp133	1.82
UNC1999 2μM R03 exp155	1.82
Adefovir 20μM R07 exp332	1.84
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.88
Hypoxia 5%O2 R04 exp191	1.92
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.98
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.19
proTAME 5μM R04 exp187	2.3
2-Methoxyestradiol 0.55μM R07 exp310	2.32
UMK57 0.6μM R03 exp107	2.36
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.52
BI-D1870 2μM R04 exp162	2.56

Global Fraction of Cell Lines Where Essential: 732/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	4/5

Expression Distribution