Table of Contents

NN-Dimethylsphingosine 2.5μM R08 exp508

Mechanism of Action

Inhibits sphingosine kinase, blocks sphingosine 1-phosphate (SPP) formation

Technical Notes

Protein References

  • PubChem Name: N,N-Dimethylsphingosine
  • Synonyms: N/A
  • CAS #: 119567-63-4
  • PubChem CID: 5282309
  • IUPAC: (E,2S,3R)-2-(dimethylamino)octadec-4-ene-1,3-diol
  • INCHI Name: InChI=1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
  • INCHI Key: YRXOQXUDKDCXME-YIVRLKKSSA-N
  • Molecular Weight: 327.5
  • Canonical SMILES: CCCCCCCCCCCCCC=CC(C(CO)N(C)C)O
  • Isomeric SMILES: CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)N(C)C)O
  • Molecular Formula: C20H41NO2

Protein Supplier

  • Supplier Name: Toronto Research Chemicals
  • Catalog #: D479250
  • Lot #: 5-EQJ-177-1

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H41NO2 328.32101; found 328.32233

Dose Response Curve

  • Platform ID: Dimethylshingosin
  • Min: -2.8924; Max: 99.8117





IC Concentration (µM)
IC10 1.3900
IC20 2.0420
IC30 2.6360
IC40 3.2510
IC50 3.9400
IC60 4.7760
IC70 5.8890
IC80 7.6050
IC90 11.1700


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
9/0ScoresViewViewViewViewView