Clomiphene 4.4μM R02 exp68

Mechanism of Action

Nonsteroidal selective estrogen receptor modulator (SERM), mixed agonist and antagonist of ER

  • Class / Subclass 1: Metabolism / Hormone Antagonist
  • Class / Subclass 2: Gene Regulation / Nuclear Receptor Ligand

Technical Notes

Compound References

  • PubChem Name: Clomiphene citrate
  • Synonyms: Clomifene citrate
  • CAS #: 50-41-9
  • PubChem CID: 3033832
  • IUPAC: 2-[4-[(Z)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid
  • INCHI Name: InChI=1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
  • INCHI Key: PYTMYKVIJXPNBD-OQKDUQJOSA-N
  • Molecular Weight: 598.1
  • Canonical SMILES: CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
  • Isomeric SMILES: CCN(CC)CCOC1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\\Cl)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
  • Molecular Formula: C32H36ClNO8

Compound Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S2561
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C26H28ClNO 406.19322; found 406.19508

Dose Response Curve

  • Platform ID: Clomiphene_citrate
  • Min: -3.7031; Max: 98.5235





IC Concentration (µM)
IC10 N/A
IC20 3.8615
IC30 4.2390
IC40 4.5759
IC50 4.9085
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 02
  • Dose: 4.4µM
  • Days of incubation: 8
  • Doublings: 3.7
  • Numbers of reads: 13597019

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
92/22ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1