CTDNEP1

Entrez Summary: N/A
UniProt Summary: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. {ECO:0000269|PubMed:17420445, ECO:0000269|PubMed:22134922}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BH1 1μM R04 exp169	-3.58
Vemurafenib 6.6μM R02 exp89	-2.97
Vemurafenib 6.6μM R08 exp434	-2.62
Ibrutinib 10μM R08 exp442	-2.38
CFI-400945 25μM R08 exp469	-2.31
Thapsigargin 0.005μM R07 exp407	-2.24
Tubacin 1.6μM R07 exp416	-2.24
Clomiphene 4.4μM R02 exp68	-2.2
Cyclosporin-A 0.8μM R07 exp347	-2.2
Q15 2.7μM R02 exp79	-2.07
Golgicide-A 4μM R03 exp122	-2.02
OICR-9429 10μM R03 exp142	-2
UM0125461 0.74μM R02 exp84	-1.88
Q15 1 to 2μM on day4 R04 exp164	-1.82
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.81
AICAR 240μM R03 exp116	-1.74
Colchicine 0.009μM R05 exp215	-1.71
MLN-4924 2μM R00 exp22	1.72
Actinomycin-D 0.01μM R00 exp4	1.76
Brefeldin A 0.02μM R00 exp8	1.89
5-Fluorouracil 20μM R00 exp2	1.97
MS023 7μM R03 exp135	2.21
Pimelic-diphenylamide-106 5μM R00 exp28	2.24

Global Fraction of Cell Lines Where Essential: 15/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	9/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Expression Distribution

Nem1-Spo7 phosphatase complex
positive regulation of triglyceride biosynthetic process
mitotic nuclear envelope disassembly
membrane disassembly
nuclear envelope disassembly
regulation of triglyceride biosynthetic process
positive regulation of triglyceride metabolic process
regulation of triglyceride metabolic process
phosphoprotein phosphatase activity
nuclear envelope organization
protein serine/threonine phosphatase activity
positive regulation of lipid biosynthetic process
lipid droplet
mesoderm development
nucleus organization
positive regulation of lipid metabolic process
positive regulation of canonical Wnt signaling pathway
protein localization to nucleus
positive regulation of Wnt signaling pathway
nuclear envelope
regulation of lipid biosynthetic process
protein dephosphorylation
nuclear membrane
regulation of canonical Wnt signaling pathway
dephosphorylation
regulation of Wnt signaling pathway
regulation of lipid metabolic process
cellular component disassembly
endomembrane system organization
mitotic cell cycle process
mitotic cell cycle
gamete generation
protein localization to organelle
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
membrane organization
endoplasmic reticulum membrane
multi-organism reproductive process
cell cycle process