TFAM

Entrez Summary: This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
UniProt Summary: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:19304746, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:22037171, ECO:0000269|PubMed:22037172, ECO:0000269|PubMed:22841477}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 89/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	2/28
bone	2/26
breast	6/33
central nervous system	1/56
cervix	1/4
colorectal	3/17
esophagus	3/13
fibroblast	0/1
gastric	1/16
kidney	4/21
liver	3/20
lung	11/75
lymphocyte	3/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	4/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	5/29
uterus	1/5

Expression Distribution

mitochondrial promoter sequence-specific DNA binding
transcription initiation from mitochondrial promoter
mitochondrial transcription
DNA binding, bending
transcription coactivator binding
mitochondrial RNA metabolic process
mitochondrial nucleoid
heat shock protein binding
mitochondrial respiratory chain complex assembly
mitochondrial gene expression
DNA-templated transcription, initiation
mitochondrial matrix
chromatin binding
sequence-specific DNA binding
mitochondrion organization
protein-containing complex
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
cellular protein-containing complex assembly
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
RNA binding
positive regulation of transcription, DNA-templated
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
protein-containing complex subunit organization
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process