MRPL42
Gene Information
- Official Symbol: MRPL42
- Official Name: mitochondrial ribosomal protein L42
- Aliases and Previous Symbols: N/A
- Entrez ID: 28977
- UniProt: Q9Y6G3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| MRP-S32 |
GO Terms
| mitochondrial small ribosomal subunit |
| mitochondrial large ribosomal subunit |
| mitochondrial translational termination |
| mitochondrial translational elongation |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| protein-containing complex disassembly |
| translation |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| mitochondrion |
| RNA binding |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hydroxyurea 100μM R07 exp329 | 1.8 |
| LJH685 50μM R08 exp433 | 1.85 |
| LLY-284 2.6μM R06 exp291 | 1.92 |
| CR131-b 0.005μM R08 exp474 | 1.95 |
| GSK-J4 1.5μM R08 exp441 | 2.23 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| DAP3 | 0.595 |
| MRP63 | 0.587 |
| HSD17B10 | 0.584 |
| MRPS21 | 0.583 |
| MRPL21 | 0.582 |
| MRPS6 | 0.578 |
| NARS2 | 0.576 |
| MRPS34 | 0.571 |
| QRSL1 | 0.554 |
| MRPS5 | 0.553 |
| MRPS14 | 0.552 |
| YARS2 | 0.549 |
| MRPL47 | 0.546 |
| EARS2 | 0.541 |
| PARS2 | 0.538 |
| SUPV3L1 | 0.537 |
| DARS2 | 0.534 |
| MRPS26 | 0.519 |
| LARS2 | 0.516 |
| GFM1 | 0.515 |
| RARS2 | 0.515 |
| WBSCR16 | 0.514 |
| MRPL45 | 0.514 |
| MRPL23 | 0.514 |
| HARS2 | 0.513 |
| SELRC1 | 0.513 |
| MRPS10 | 0.511 |
| COX16 | 0.51 |
| GFM2 | 0.509 |
| TARS2 | 0.501 |
| MRPL3 | 0.5 |
| MRPS9 | 0.495 |
| MRPS35 | 0.493 |
| SCO2 | 0.493 |
| MRPL53 | 0.493 |
| MRPS16 | 0.491 |
| VARS2 | 0.49 |
| MRPS18A | 0.489 |
| METTL17 | 0.489 |
| TRUB2 | 0.489 |
| DDX28 | 0.486 |
| POLRMT | 0.485 |
| MARS2 | 0.484 |
| MRPS23 | 0.483 |
| MRPL12 | 0.483 |
| FTSJ2 | 0.482 |
| PET112 | 0.477 |
| AIFM1 | 0.476 |
| PNPT1 | 0.476 |
| NDUFB11 | 0.476 |
| KIAA0391 | 0.474 |
| RBFA | 0.473 |
| TUFM | 0.472 |
| MRPL17 | 0.468 |
| MRPL15 | 0.467 |
| PTCD3 | 0.462 |
| NDUFA3 | 0.462 |
| MRPS12 | 0.46 |
| SARS2 | 0.459 |
| MRPS25 | 0.457 |
| TFAM | 0.457 |
| MTPAP | 0.456 |
| POLG2 | 0.453 |
| FASTKD5 | 0.451 |
| MRPL33 | 0.448 |
| MRPS33 | 0.446 |
| COA3 | 0.445 |
| MRPS2 | 0.442 |
| MRPL13 | 0.441 |
| NDUFC2 | 0.441 |
| MRPL39 | 0.44 |
| ATP5SL | 0.44 |
| SLC25A26 | 0.44 |
| MRPS22 | 0.439 |
| FARS2 | 0.439 |
| BCS1L | 0.436 |
| TEFM | 0.434 |
| MRPS11 | 0.434 |
| MRPL44 | 0.434 |
| MRPL11 | 0.434 |
| COX19 | 0.432 |
| MRPL46 | 0.431 |
| AARS2 | 0.431 |
| COX17 | 0.431 |
| GATC | 0.43 |
| NDUFA1 | 0.43 |
| RPUSD4 | 0.428 |
| UQCR10 | 0.426 |
| CHCHD1 | 0.426 |
| MRPS7 | 0.425 |
| MTERFD1 | 0.423 |
| MRPL4 | 0.422 |
| MRPL51 | 0.421 |
| MRPL43 | 0.421 |
| MRPL52 | 0.421 |
| MRPL55 | 0.42 |
| NDUFB9 | 0.419 |
| MRPL18 | 0.419 |
| GTPBP10 | 0.416 |
| MRPS24 | 0.414 |
| MTG1 | 0.413 |
| C10orf2 | 0.412 |
| COX11 | 0.412 |
| C12orf65 | 0.412 |
| MTG2 | 0.412 |
| RNASEH1 | 0.412 |
| MRPS27 | 0.41 |
| CARS2 | 0.408 |
| MRPL36 | 0.408 |
| RNMTL1 | 0.407 |
| COX7B | 0.404 |
| NDUFAF7 | 0.404 |
| PGM3 | 0.404 |
| MTIF2 | 0.404 |
| PET117 | 0.402 |
| COA6 | 0.401 |
| MRPL34 | 0.4 |
| WARS2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1924
- Expression level (log2 read counts): 6.98
Expression Distribution
MRPL42 Expression in NALM6 Cells: 6.98
