Table of Contents

CB-839 10μM R05 exp224

Mechanism of Action

Inhibits glutaminase (GLS1), reversible

Technical Notes

Compound References

  • PubChem Name: CB-839
  • Synonyms: CB-839
  • CAS #: 1439399-58-2
  • PubChem CID: 71577426
  • IUPAC: N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
  • INCHI Name: InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)
  • INCHI Key: PRAAPINBUWJLGA-UHFFFAOYSA-N
  • Molecular Weight: 571.6
  • Canonical SMILES: C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F
  • Isomeric SMILES: N/A
  • Molecular Formula: C26H24F3N7O3S

Compound Supplier

  • Supplier Name: N/A
  • Catalog #: N/A
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C26H24F3N7O3S 572.16862; found 572.17021

Dose Response Curve

  • Platform ID: CB-839
  • Min: -29.0403; Max: 20.4182





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
4/5ScoresViewViewViewViewView