ATP13A1

Entrez Summary: N/A
UniProt Summary: Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. {ECO:0000269|PubMed:24392018}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 15μM R08 exp443	-3.03
UM0129480 7μM R02 exp85	-2.38
Bortezomib 0.005μM R00 exp6	-2.27
THZ531 0.225μM R08 exp444	-2.12
PU-H71 1μM R08 exp515	-2.03
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2
Docosahexaenoic-acid 50μM R07 exp356	-1.96
Vinblastine 0.2μM R03 exp108	-1.82
MS023 2μM R03 exp134	-1.8
CB-5083 0.4μM R08 exp468	-1.77
Rucaparib 6.5μM R08 exp520	-1.76
THZ1 0.06μM R08 exp531	-1.73
BI-2536 0.02μM R03 exp96	-1.72
Ribavirin 10μM R01 exp52	2.13

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution