PDAP1

Entrez Summary: The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010].
UniProt Summary: Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rifampicin 10μM R00 exp32	-2.46
BH1 1μM R04 exp169	-2.45
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.42
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.34
Vemurafenib 6.6μM R02 exp89	-2.27
I-BRD9 4μM R07 exp365	-2.21
TRAIL 5ng/ml R00 exp35	-2.19
Golgicide-A 4μM R03 exp122	-2.17
Clomiphene 4.4μM R02 exp68	-2.14
proTAME 5μM R04 exp187	-2.12
Chloroquine 32μM R08 exp470	-2.06
BI-D1870 2μM R04 exp162	-2.03
Thalidomide 20μM R07 exp406	-1.98
Dynasore 10μM R04 exp180	-1.93
Wortmannin 0.5μM R00 exp37	-1.86
Wortmannin 5μM R00 exp38	-1.83
Cisplatin 0.35μM R06 exp273	-1.79
Trichostatin-A 0.06μM R07 exp415	-1.79
SGC0946 7μM R03 exp151	-1.75
TRAIL 50ng/ml R00 exp36	-1.74
Ethanol 0.003 R08 exp437	-1.73
Fluvastatin 2.2μM R06 exp282	-1.73
3-Bromopyruvate 7μM R04 exp175	-1.71
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.71
Epothilone-B 0.0015μM R05 exp231	-1.71
Vemurafenib 6.6μM R08 exp434	-1.71
Mdivi-1 15μM R05 exp217	1.94
Deguelin 0.15μM R05 exp209	2.05
Nocodazole 0.2μM R02 exp64	2.11

Global Fraction of Cell Lines Where Essential: 462/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	17/28
blood	20/28
bone	15/26
breast	17/33
central nervous system	28/56
cervix	1/4
colorectal	15/17
esophagus	4/13
fibroblast	1/1
gastric	9/16
kidney	15/21
liver	17/20
lung	49/75
lymphocyte	10/16
ovary	10/26
pancreas	18/24
peripheral nervous system	11/16
plasma cell	5/15
prostate	1/1
skin	18/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	20/29
uterus	3/5

Expression Distribution