Table of Contents

CAY10603 0.55μM R08 exp467

Mechanism of Action

Inhibits HDAC6, selective over other HDACs

Technical Notes

Protein References

  • PubChem Name: HDAC6 Inhibitor
  • Synonyms: BML-281
  • CAS #: 1045792-66-2
  • PubChem CID: 24951314
  • IUPAC: tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
  • INCHI Name: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
  • INCHI Key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N
  • Molecular Weight: 446.5
  • Canonical SMILES: CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO
  • Isomeric SMILES: N/A
  • Molecular Formula: C22H30N4O6

Protein Supplier

  • Supplier Name: Med Chem Express
  • Catalog #: HY-18613
  • Lot #: 14350

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22H30N4O6 447.22381; found 447.22501

Dose Response Curve

  • Platform ID: CAY10603
  • Min: -14.1695; Max: 99.7520





IC Concentration (µM)
IC10 0.4855
IC20 0.5746
IC30 0.6427
IC40 0.7046
IC50 0.7665
IC60 0.8339
IC70 0.9141
IC80 1.0230
IC90 1.2100


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
8/0ScoresViewViewViewViewView