LRPPRC

Gene Information

Official Symbol: LRPPRC
Official Name: leucine rich pentatricopeptide repeat containing
Aliases and Previous Symbols: N/A
Entrez ID: 10128
UniProt: P42704
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012].
UniProt Summary: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 10μM R06 exp288	-2.11
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.85
BAY-598 4μM R05 exp220	-1.75
Caffeine 2600μM R08 exp463	1.71
Hinokiflavone 12μM R08 exp487	1.75
Azithromycin 100μM R08 exp452	1.79
BML-284 0.09μM R08 exp460	1.84
MK2206 4μM R08 exp504	1.87
PU-H71 1μM R08 exp515	1.88
Dynasore 7μM R08 exp436	1.89
Genistein 15μM R07 exp360	1.9
Hippuristanol 0.12μM R08 exp488	1.99
Vemurafenib 6.6μM R08 exp434	2.2
Pyridostatin 4μM R05 exp240	2.25
iCRT14 30μM R08 exp492	2.32
Hydroxyurea 100μM R07 exp329	2.43
Chloroquine 32μM R08 exp470	2.58
Thimerosal 0.85μM R08 exp529	2.71

Gene	Correlation
SELRC1	0.526
MRPS25	0.525
COQ2	0.525
PET117	0.511
COA6	0.51
FASTKD5	0.505
NDUFV1	0.503
NARS2	0.501
MRPS6	0.498
COA3	0.497
RPUSD4	0.492
EARS2	0.489
TARS2	0.486
MRPL47	0.485
MRPS21	0.484
MRPS10	0.484
MRPS18A	0.484
MRPL4	0.483
MRPL21	0.482
VARS2	0.48
FTSJ2	0.479
MRPS34	0.476
YARS2	0.474
MRPS35	0.471
MRP63	0.471
QRSL1	0.47
SCO2	0.469
MRPS27	0.469
COX15	0.468
MRPS24	0.464
TRUB2	0.463
COX7B	0.463
DAP3	0.461
MRPL23	0.459
RBFA	0.459
AARS2	0.458
PET112	0.458
MRPS14	0.457
GTPBP6	0.455
CARS2	0.454
MRPL53	0.454
HSD17B10	0.454
FASTKD2	0.453
GFM1	0.45
MRPS12	0.445
MRPL55	0.444
MTRF1L	0.444
MRPL18	0.444
KIAA0391	0.443
FARS2	0.441
MRPS16	0.44
HIGD2A	0.44
RNASEH1	0.44
PNPT1	0.439
SUPV3L1	0.439
PTCD3	0.438
MRPS26	0.434
SARS2	0.432
MRPL22	0.431
MRPL1	0.429
MRPL3	0.428
MRPS23	0.426
NDUFA3	0.425
MRPL43	0.425
ACAD9	0.424
LARS2	0.423
WBSCR16	0.423
TBRG4	0.423
METTL17	0.423
RPUSD3	0.422
MRPL45	0.421
MTG1	0.421
COX6B1	0.419
MTPAP	0.419
NDUFAF7	0.418
NDUFS2	0.417
MRPL24	0.415
NDUFB11	0.415
MTERFD2	0.415
COX16	0.414
MARS2	0.414
DDX28	0.413
SLC31A1	0.412
C12orf65	0.412
MRPL33	0.411
ALAS1	0.407
COX18	0.405
COX6A1	0.404
RARS2	0.404
PARS2	0.404
AIFM1	0.403
MRPL52	0.401
WARS2	0.4

Global Fraction of Cell Lines Where Essential: 163/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	9/28
blood	5/28
bone	5/26
breast	11/33
central nervous system	9/56
cervix	1/4
colorectal	5/17
esophagus	3/13
fibroblast	1/1
gastric	4/16
kidney	3/21
liver	5/20
lung	17/75
lymphocyte	4/16
ovary	1/26
pancreas	3/24
peripheral nervous system	1/16
plasma cell	4/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	5/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 637
Expression level (log2 read counts): 8.55

Expression Distribution

negative regulation of mitochondrial RNA catabolic process
regulation of mitochondrial RNA catabolic process
mitochondrion transport along microtubule
establishment of mitochondrion localization, microtubule-mediated
establishment of mitochondrion localization
nuclear outer membrane
regulation of mitochondrial translation
regulation of mitochondrial gene expression
condensed nuclear chromosome
beta-tubulin binding
mitochondrial nucleoid
nuclear inner membrane
mitochondrion localization
negative regulation of RNA catabolic process
organelle transport along microtubule
single-stranded DNA binding
mRNA transport
ribonucleoprotein complex
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
nucleic acid transport
RNA transport
establishment of RNA localization
actin filament binding
RNA localization
microtubule binding
nucleobase-containing compound transport
negative regulation of cellular catabolic process
microtubule-based movement
ubiquitin protein ligase binding
negative regulation of catabolic process
microtubule
regulation of translation
establishment of organelle localization
cytoskeleton
regulation of cellular amide metabolic process
posttranscriptional regulation of gene expression
organelle localization
microtubule-based process