2-Deoxy-D-glucose 800μM R05 exp214
Mechanism of Action
Inhibits phosphoglucoisomerase, competitive, blocks glycolysis
- Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor
Technical Notes
Compound References
- PubChem Name: Deoxyglucose
- Synonyms: 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose
- CAS #: 154-17-6
- PubChem CID: 108223
- IUPAC: (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
- INCHI Name: InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
- INCHI Key: VRYALKFFQXWPIH-PBXRRBTRSA-N
- Molecular Weight: 164.16
- Canonical SMILES: C(C=O)C(C(C(CO)O)O)O
- Isomeric SMILES: C(C=O)[C@H]([C@@H]([C@@H](CO)O)O)O
- Molecular Formula: C6H12O5
Compound Supplier
- Supplier Name: Chem-Impex International
- Catalog #: 21916
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C6H12O5 187.05769; found 187.05708
Dose Response Curve
- Platform ID: 2-deoxy-D-glucose
- Min: -9.1371; Max: 57.2932
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.5031 |
| IC30 | 0.7657 |
| IC40 | 1.0805 |
| IC50 | 1.4822 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 05
- Dose: 800µM
- Days of incubation: 8
- Doublings: 2.3
- Numbers of reads: 17052896
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 10/60 | Scores |
2-Deoxy-D-glucose 800μM R05 exp214
2-Deoxy-D-glucose 800μM R05 exp214 vs MS023 7μM R03 exp135
2-Deoxy-D-glucose 800μM R05 exp214 vs MS023 2μM R03 exp134
2-Deoxy-D-glucose 800μM R05 exp214 vs Ethanol 0.01 R05 exp234
2-Deoxy-D-glucose 800μM R05 exp214 vs Olaparib 4μM R08 exp512
2-Deoxy-D-glucose 800μM R05 exp214 vs UM0129480 7μM R02 exp85
2-Deoxy-D-glucose 800μM R05 exp214 vs Artemisinin 50μM R08 exp450
2-Deoxy-D-glucose 800μM R05 exp214 vs Milciclib 2μM R08 exp502
2-Deoxy-D-glucose 800μM R05 exp214 vs 6-Thio-2-deoxyguanosine 2μM R06 exp259
2-Deoxy-D-glucose 800μM R05 exp214 vs Hippuristanol 0.12μM R08 exp488
2-Deoxy-D-glucose 800μM R05 exp214 vs CB-5083 0.4μM R08 exp468
2-Deoxy-D-glucose 800μM R05 exp214 vs Cytochalasin-B 5μM R07 exp349
2-Deoxy-D-glucose 800μM R05 exp214 vs Thapsigargin 0.005μM R07 exp407
2-Deoxy-D-glucose 800μM R05 exp214 vs Hippuristanol 0.12μM R08 exp489 no dilution day6
2-Deoxy-D-glucose 800μM R05 exp214 vs ML-792 0.2μM R08 exp505
2-Deoxy-D-glucose 800μM R05 exp214 vs MLN-4924 0.2μM R00 exp21
2-Deoxy-D-glucose 800μM R05 exp214 vs SNS-032 15μM R08 exp443
2-Deoxy-D-glucose 800μM R05 exp214 vs AICAR 240μM R05 exp211
2-Deoxy-D-glucose 800μM R05 exp214 vs FK-506 30μM R07 exp359
