Cryptotanshinone 12μM R05 exp227

Putative acetylcholinesterase and STAT3 inhibitor

PubChem Name: Cryptotanshinone
Synonyms: Cryptotanshinon; Tanshinone c
CAS #: 35825-57-1
PubChem CID: 160254
IUPAC: (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g][1]benzofuran-10,11-dione
INCHI Name: InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
INCHI Key: GVKKJJOMQCNPGB-JTQLQIEISA-N
Molecular Weight: 296.4
Canonical SMILES: CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
Isomeric SMILES: C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
Molecular Formula: C19H20O3

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
34/10	Scores	View	View	View	View	View

Screen	Correlation	Plot
Quercetin 20μM R08 exp517	0.073	View
Hydroxyurea 100μM R07 exp329	0.073	View
FK-506 30μM R07 exp359	0.072	View
∆-9-Tetrahydrocannabinol 30μM R08 exp445	0.07	View
Deferoxamine 11μM R07 exp350	0.063	View
Tubacin 1.6μM R07 exp416	0.062	View
WYE-354 6μM R02 exp90	0.061	View
JQ1 0.8μM R08 exp435	0.06	View
Dynasore 7μM R08 exp436	0.059	View
Dynasore 10μM R04 exp180	0.059	View
Docosahexaenoic-acid 50μM R07 exp356	0.057	View
Vemurafenib 6.6μM R02 exp89	0.057	View
Pterostilbene 16μM R02 exp78	0.054	View
UM0129480 7μM R02 exp85	0.053	View
Salubrinal 20μM R07 exp399	0.053	View
FTY720 3μM R08 exp483	0.051	View
Bafilomycin-A1 0.009μM R08 exp454	0.086	View
BS-181 20μM R08 exp461	0.077	View
Clomiphene 4.4μM R02 exp68	0.065	View
BH1 1μM R04 exp169	0.064	View
3-Bromopyruvate 7μM R04 exp175	0.063	View
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	0.062	View
CB-5083 0.4μM R08 exp468	0.059	View
BVD-523 15μM R02 exp67	0.058	View
Cannabidiol 13μM R08 exp465	0.056	View
All-trans-Retinoic-Acid 40μM R07 exp334	0.054	View
Cannabidiol 20μM R08 exp466	0.053	View
Artemisinin 50μM R08 exp450	0.053	View
Bisphenol F 50μM R08 exp457	0.053	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.051	View
Aphidicolin 0.4μM R08 exp440	0.051	View

GO Term	Fold Change	Genes
GATOR1 complex	591.79	NPRL2,NPRL3
protein localization to Golgi apparatus	61.22	COG7,ARL1,ARFRP1
transition metal ion transmembrane transporter activity	57.74	SLC39A11,SLC39A9,ATP2C1,SLC25A28
negative regulation of TORC1 signaling	57.74	NPRL2,PRKAA1,TSC2,NPRL3
negative regulation of TOR signaling	35.87	NPRL2,PRKAA1,TSC2,NPRL3
regulation of TORC1 signaling	27.52	NPRL2,PRKAA1,TSC2,NPRL3
transition metal ion transport	25.18	SLC39A11,SLC39A9,ATP2C1,SLC25A28
cellular response to starvation	17.51	NPRL2,PRKAA1,TSC2,XPR1,NPRL3
response to starvation	14.23	NPRL2,PRKAA1,TSC2,XPR1,NPRL3
cellular response to nutrient levels	12.81	NPRL2,PRKAA1,TSC2,XPR1,NPRL3
regulation of autophagy	10.20	NPRL2,ATP6V0A2,PRKAA1,TSC2,ATP6V1G1,NPRL3
inorganic ion homeostasis	10.10	SLC39A9,ATP6V0A2,ATP2C1,ANKH,XPR1,CCDC22,ATP6V1G1
cellular homeostasis	9.30	PRDX1,SLC39A9,ATP6V0A2,PRKAA1,ATP2C1,ANKH,CLCN3,XPR1,CCDC22,ATP6V1G1
intracellular chemical homeostasis	8.95	SLC39A9,ATP6V0A2,PRKAA1,ATP2C1,CLCN3,XPR1,CCDC22,ATP6V1G1
monoatomic cation homeostasis	8.72	SLC39A9,ATP6V0A2,ATP2C1,ANKH,CLCN3,CCDC22,ATP6V1G1
monoatomic ion homeostasis	8.56	SLC39A9,ATP6V0A2,ATP2C1,ANKH,CLCN3,CCDC22,ATP6V1G1
inorganic molecular entity transmembrane transporter activity	7.94	SLC39A11,SLC39A9,ATP6V0A2,ATP2C1,SLC25A28,ANKH,CLCN3,XPR1,ATP6V1G1
inorganic ion transmembrane transport	7.44	SLC39A11,SLC39A9,ATP6V0A2,ATP2C1,SLC25A28,ANKH,CLCN3,XPR1,ATP6V1G1
chemical homeostasis	6.39	SLC39A9,ATP6V0A2,PRKAA1,ATP2C1,ANKH,CLCN3,XPR1,CCDC22,ATP6V1G1