EGR2
Gene Information
- Official Symbol: EGR2
- Official Name: early growth response 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1959
- UniProt: P11161
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
- UniProt Summary: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. {ECO:0000269|PubMed:21836637}.
Pfam Domains GO Terms
Pfam Domains
| zf-C2H2 |
| DUF3446 |
GO Terms
| rhombomere 5 morphogenesis |
| rhombomere 3 formation |
| rhombomere 5 formation |
| rhombomere formation |
| rhombomere 3 morphogenesis |
| rhombomere morphogenesis |
| rhombomere 3 development |
| central nervous system segmentation |
| brain segmentation |
| rhombomere 5 development |
| rhombomere development |
| SUMO ligase activity |
| facial nerve structural organization |
| facial nerve morphogenesis |
| facial nerve development |
| cranial nerve structural organization |
| HMG box domain binding |
| anatomical structure arrangement |
| preganglionic parasympathetic fiber development |
| parasympathetic nervous system development |
| rhythmic behavior |
| motor neuron axon guidance |
| cranial nerve morphogenesis |
| Schwann cell differentiation |
| autonomic nervous system development |
| skeletal muscle cell differentiation |
| cranial nerve development |
| regulation of neuronal synaptic plasticity |
| RNA polymerase II activating transcription factor binding |
| protein sumoylation |
| peripheral nervous system development |
| nerve development |
| segmentation |
| fat cell differentiation |
| myelination |
| axon ensheathment |
| ensheathment of neurons |
| skeletal muscle tissue development |
| skeletal muscle organ development |
| protein export from nucleus |
| hindbrain development |
| nuclear export |
| glial cell differentiation |
| regulation of synaptic plasticity |
| regulation of ossification |
| gliogenesis |
| transcription regulatory region DNA binding |
| response to insulin |
| learning or memory |
| axon guidance |
| neuron projection guidance |
| nucleocytoplasmic transport |
| nuclear transport |
| rhythmic process |
| striated muscle tissue development |
| ubiquitin protein ligase binding |
| muscle organ development |
| muscle tissue development |
| cognition |
| peptidyl-lysine modification |
| regionalization |
| axonogenesis |
| response to peptide hormone |
| chromatin binding |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| pattern specification process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| response to peptide |
| muscle structure development |
| neuron projection morphogenesis |
| transcription by RNA polymerase II |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cell part morphogenesis |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| behavior |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| neuron projection development |
| DNA-binding transcription factor activity |
| intracellular membrane-bounded organelle |
| cell morphogenesis |
| brain development |
| protein modification by small protein conjugation |
| head development |
| neuron development |
| cellular component morphogenesis |
| peptidyl-amino acid modification |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| central nervous system development |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| response to organonitrogen compound |
| neuron differentiation |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| locomotion |
| nervous system process |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| establishment of localization in cell |
| nitrogen compound transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.594 |
| C14orf93 | 0.503 |
| TFIP11 | 0.496 |
| TBC1D3G | 0.495 |
| TBC1D3H | 0.494 |
| SLC6A17 | 0.481 |
| VASN | 0.48 |
| TCEB3CL2 | 0.478 |
| NUPL1 | 0.477 |
| TCEB3C | 0.467 |
| PSAP | 0.467 |
| TBC1D3F | 0.464 |
| RPS2 | 0.459 |
| EIF4A3 | 0.458 |
| TCEB3CL | 0.455 |
| CKAP5 | 0.454 |
| ORC6 | 0.453 |
| PSMB4 | 0.45 |
| SMTN | 0.448 |
| CDC6 | 0.445 |
| ORC1 | 0.44 |
| TPX2 | 0.44 |
| FAM231A | 0.44 |
| FAM231C | 0.44 |
| TBC1D3 | 0.437 |
| SLC4A1 | 0.432 |
| GOLGA8O | 0.431 |
| TP53TG3B | 0.43 |
| TP53TG3 | 0.429 |
| TP53TG3C | 0.429 |
| CEP192 | 0.428 |
| PSMB3 | 0.428 |
| POLR2J3 | 0.428 |
| ISCU | 0.428 |
| SUPT5H | 0.427 |
| CCNA2 | 0.424 |
| AAMP | 0.423 |
| C1QTNF9B | 0.422 |
| S1PR4 | 0.421 |
| RRN3 | 0.419 |
| EXOSC5 | 0.418 |
| MSH5 | 0.418 |
| APRT | 0.418 |
| GAR1 | 0.418 |
| TBC1D3C | 0.416 |
| COPG1 | 0.416 |
| PSMB2 | 0.415 |
| GOLGA6L1 | 0.415 |
| CDCA3 | 0.412 |
| RBM39 | 0.412 |
| KIF3C | 0.412 |
| MED14 | 0.41 |
| DOCK6 | 0.409 |
| AQR | 0.409 |
| GON4L | 0.408 |
| TUBA8 | 0.408 |
| HIST1H2BE | 0.407 |
| PSMD3 | 0.407 |
| CHD4 | 0.406 |
| RPS12 | 0.406 |
| CBWD3 | 0.405 |
| CACTIN | 0.405 |
| TBC1D3L | 0.405 |
| TBC1D3K | 0.404 |
| TBC1D3E | 0.404 |
| UTP3 | 0.404 |
| TBC1D3I | 0.403 |
| IK | 0.403 |
| OR10G3 | 0.402 |
| DDTL | 0.402 |
| RRP7A | 0.401 |
| RBBP5 | 0.401 |
| CHAF1A | 0.4 |
| ADD2 | 0.4 |
| ZFAND5 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1801
- Expression level (log2 read counts): -0.84
Expression Distribution
EGR2 Expression in NALM6 Cells: -0.84
