GID4

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 15μM R08 exp443	-1.87
Cycloheximide 0.2μM R00 exp15	1.72
PF-06409577 20μM R07 exp389	1.72
QNZ 0.01μM R05 exp241	1.74
Vinorelbine 0.001μM R05 exp249	1.77
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.83
All-trans-Retinoic-Acid 40μM R07 exp334	1.84
Epothilone-B 0.0015μM R05 exp231	1.84
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.87
Fluvastatin 2.2μM R06 exp282	2.05
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.05
VHL-ligand-1 20μM R07 exp421	2.28
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.34
NN-Diethyl-meta-toluamide 100μM R05 exp237	2.38
Cerivastatin 0.15μM R05 exp226	2.99

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquitin ligase complex
ubiquitin protein ligase activity
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
organic substance catabolic process
cellular catabolic process