SEPHS2

Gene Information

Official Symbol: SEPHS2
Official Name: selenophosphate synthetase 2
Aliases and Previous Symbols: N/A
Entrez ID: 22928
UniProt: Q99611
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Synthesizes selenophosphate from selenide and ATP.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Palbociclib 1μM R07 exp382	-3.31
Rotenone 2μM R00 exp33	-3.26
Docosahexaenoic-acid 50μM R07 exp356	-3
Epigallocatechin gallate 20μM R05 exp230	-2.79
Epothilone-B 0.0015μM R05 exp231	-2.79
5-Fluorouracil 20μM R00 exp2	-2.75
Mubritinib 0.2μM R01 exp48	-2.66
Pimelic-diphenylamide-106 5μM R00 exp28	-2.61
2-Methoxyestradiol 0.55μM R07 exp310	-2.54
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.5
TRAIL 50ng/ml R00 exp36	-2.49
Calcium Ionophore 0.4μM R07 exp342	-2.46
Menadione 5μM R06 exp292	-2.46
Etoposide 1μM R00 exp19	-2.44
UM0131023 0.05μM R05 exp248	-2.41
Nocodazole 0.2μM R00 exp24	-2.34
S-trityl-L-cysteine 0.5μM R05 exp243	-2.28
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.24
Arsenate 40μM R06 exp264	-2.22
Celastrol 0.12μM R05 exp225	-2.2
Rapamycin 2μM R07 exp306	-2.2
Tubacin 1.6μM R07 exp416	-2.18
Bortezomib 0.05μM R00 exp7	-2.17
Tubastatin-A 2.5μM R07 exp417	-2.17
Etoposide 0.1μM R05 exp198	-2.16
Vinblastine 0.2μM R03 exp108	-2.16
Artemisinin 50μM R08 exp450	-2.15
Tunicamycin 0.04μM R07 exp418	-2.12
QNZ 0.01μM R05 exp241	-2.11
Rotenone 0.07μM R08 exp431	-2.11
Ammonium tetrathiomolybdate 10μM R08 exp448	-2.08
Genistein 15μM R07 exp360	-2.08
Bortezomib 0.005μM R00 exp6	-2.06
Diepoxybutane 3μM R07 exp354	-2.05
Brefeldin A 0.02μM R00 exp8	-2.04
Docetaxel 0.002μM R01 exp45	-2.01
DABN 20μM R00 exp17	-2
Parthenolide 2.5μM R05 exp238	-2
TIC10 10μM R08 exp532	-1.99
CCCP 0.1μM R00 exp10	-1.98
I-BRD9 4μM R07 exp365	-1.98
Sulforaphane 9μM R08 exp525	-1.98
Sulforaphane 9μM R08 exp526 no dilution day6	-1.97
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.97
Tozasertib 0.1μM R07 exp414	-1.96
CCT251545 0.2μM R06 exp271	-1.95
Citral 75μM R06 exp275	-1.95
NMS-873 0.07μM R07 exp380	-1.94
Nocodazole 0.1μM R03 exp94	-1.94
Aphidicolin 0.4μM R08 exp440	-1.93
PF-06409577 20μM R07 exp389	-1.93
Phenformin 20μM R03 exp143	-1.91
BI-6727 0.001μM R01 exp42	-1.9
Phenformin 20μM R05 exp212	-1.9
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.89
UMK57 1μM R01 exp59	-1.89
Oligomycin-A 20μM R00 exp26	-1.88
Dexamethasone 0.006μM R07 exp351	-1.87
Rotenone 20μM R00 exp34	-1.87
CI-1040 9.5μM R08 exp472	-1.86
MLN-4924 2μM R00 exp22	-1.86
Tenofovir 10μM R07 exp405	-1.86
Taxol 0.002μM R01 exp54	-1.84
Cidofovir 10μM R07 exp345	-1.83
Latrunculin-B 10μM R07 exp374	-1.81
FBS-Wisent 0.1 R07 exp426	-1.79
Dimethyloxaloylglycine 11μM R07 exp314	-1.78
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.76
Radicicol 0.16μM R05 exp242	-1.76
BAY-598 4μM R05 exp220	-1.75
Dinaciclib 0.007μM R07 exp355	-1.75
GW501516 25μM R06 exp285	-1.74
Hydroxyurea 100μM R07 exp329	-1.73
GSK461364A 0.1μM R03 exp126	-1.72
Talazoparib 0.006μM R06 exp299	-1.72
Actinomycin-D 0.01μM R00 exp4	-1.71
PNU96415E 10μM R03 exp145	-1.71
RO-3307 4.7μM R02 exp80	-1.71
Deferoxamine 11μM R07 exp350	1.74

Global Fraction of Cell Lines Where Essential: 277/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	22/28
bone	12/26
breast	10/33
central nervous system	16/56
cervix	1/4
colorectal	2/17
esophagus	1/13
fibroblast	1/1
gastric	3/16
kidney	12/21
liver	8/20
lung	28/75
lymphocyte	12/16
ovary	9/26
pancreas	8/24
peripheral nervous system	8/16
plasma cell	9/15
prostate	0/1
skin	10/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	10/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 1305
Expression level (log2 read counts): 5.83

Expression Distribution

Gene	Correlation
PSTK	0.576
EEFSEC	0.55
GPX4	0.472
RRM1	0.461

AIRS
AIRS C

selenocysteine biosynthetic process
tRNA seleno-modification
selenide, water dikinase activity
selenocysteine metabolic process
selenium compound metabolic process
serine family amino acid biosynthetic process
serine family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
alpha-amino acid metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
ncRNA processing
cellular component
ncRNA metabolic process
small molecule biosynthetic process
RNA processing
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
phosphorylation
organonitrogen compound biosynthetic process
ATP binding
RNA metabolic process
small molecule metabolic process
gene expression