UBA5

Entrez Summary: This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016].
UniProt Summary: E1-like enzyme which activates UFM1 and SUMO2. {ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.87
Colchicine 0.009μM R05 exp215	-2.66
Rapamycin 2μM R07 exp306	-2.64
Demecolcine 0.03μM R05 exp228	-2.4
Golgicide-A 4μM R03 exp122	-2.25
Thapsigargin 0.005μM R07 exp407	-2.25
VER-155008 3.9μM R06 exp301	-2.04
Nicotinamide 2000μM R01 exp50	-2.03
Aminopterin 0.005μM R07 exp335	-1.97
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.88
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.72
A-395 10μM R05 exp218	-1.7
Etoposide 1μM R00 exp19	1.71
GSK-J4 1.5μM R08 exp441	1.71
Latrunculin-B 10μM R07 exp374	1.71
MS023 2μM R03 exp134	1.71
UM131593 0.2μM R03 exp106	1.73
Tozasertib 0.1μM R07 exp414	1.74
IWR1 50μM R08 exp495	1.78
DABN 20μM R00 exp17	1.8
Actinomycin-D 0.01μM R00 exp4	1.81
Nifuroxazide 5μM R03 exp102	1.81
Trimetrexate 0.03μM R08 exp535	1.81
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.82
Hippuristanol 0.12μM R08 exp488	1.82
Doxorubicin 0.02μM R08 exp478	1.84
Deferoxamine 11μM R07 exp350	1.86
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.86
R-DABN 8μM R03 exp111	1.89
MLN-4924 2μM R00 exp22	1.96
GSK461364A 0.1μM R03 exp126	2.01
UMK57 1μM R01 exp59	2.03
Actinomycin-D 0.001μM R00 exp3	2.05
Taxol 0.004μM R03 exp103	2.06
AICAR 240μM R03 exp116	2.11
Phenformin 20μM R03 exp143	2.19
iCRT14 30μM R08 exp492	2.26
Bortezomib 0.05μM R00 exp7	2.34
MS023 7μM R03 exp135	2.53
BI-2536 0.0042μM R03 exp95	3.14

Global Fraction of Cell Lines Where Essential: 120/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	7/28
blood	5/28
bone	1/26
breast	1/33
central nervous system	16/56
cervix	0/4
colorectal	4/17
esophagus	1/13
fibroblast	0/1
gastric	3/16
kidney	8/21
liver	8/20
lung	12/75
lymphocyte	2/16
ovary	5/26
pancreas	5/24
peripheral nervous system	0/16
plasma cell	4/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	7/29
uterus	0/5

Expression Distribution

UFM1 activating enzyme activity
protein polyufmylation
protein K69-linked ufmylation
protein ufmylation
regulation of intracellular estrogen receptor signaling pathway
regulation of intracellular steroid hormone receptor signaling pathway
neuromuscular process
response to endoplasmic reticulum stress
intracellular membrane-bounded organelle
protein modification by small protein conjugation
Golgi apparatus
protein modification by small protein conjugation or removal
nervous system process
ATP binding
cellular response to stress
system process