VPS28

Entrez Summary: This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].
UniProt Summary: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 401/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	12/28
blood	15/28
bone	19/26
breast	17/33
central nervous system	30/56
cervix	2/4
colorectal	12/17
esophagus	5/13
fibroblast	0/1
gastric	7/16
kidney	11/21
liver	13/20
lung	40/75
lymphocyte	9/16
ovary	15/26
pancreas	9/24
peripheral nervous system	7/16
plasma cell	9/15
prostate	1/1
skin	15/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	5/22
urinary tract	15/29
uterus	4/5

Expression Distribution

positive regulation of ubiquitin-dependent endocytosis
regulation of ubiquitin-dependent endocytosis
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
late endosome to vacuole transport via multivesicular body sorting pathway
ESCRT I complex
late endosome to vacuole transport
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
multivesicular body organization
multivesicular body sorting pathway
virion assembly
establishment of protein localization to vacuole
intracellular transport of virus
host cell
transport of virus
protein localization to vacuole
multi-organism localization
multi-organism transport
negative regulation of protein ubiquitination
endosome organization
ubiquitin binding
negative regulation of protein modification by small protein conjugation or removal
positive regulation of endocytosis
late endosome membrane
vacuolar transport
macroautophagy
regulation of protein ubiquitination
viral life cycle
regulation of endocytosis
endosome membrane
positive regulation of protein catabolic process
regulation of protein modification by small protein conjugation or removal
endosomal transport
early endosome
autophagy
process utilizing autophagic mechanism
protein-containing complex binding