WDR59

Entrez Summary: N/A
UniProt Summary: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J5 1.5μM R08 exp484	-2.44
Dexamethasone 0.006μM R07 exp351	-2.14
Trientine 500μM R08 exp534	-1.95
Isoniazid 100μM R08 exp494	-1.91
A-769662 20μM R07 exp331	-1.87
PT-1 25μM R07 exp392	-1.8
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.75
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.73
RO-3307 4.7μM R02 exp80	1.81
Actinomycin-D 0.001μM R00 exp3	1.82
AICAR 240μM R05 exp211	1.83
SB743921 0.001μM R05 exp244	1.84
Artemisinin 50μM R08 exp450	1.89
Atovaquone 15μM R08 exp451	1.89
MLN-4924 0.2μM R00 exp21	2.5
Etoposide 0.3μM R05 exp199	2.83

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GATOR2 complex
positive regulation of TOR signaling
cellular response to amino acid starvation
response to amino acid starvation
regulation of TOR signaling
cellular response to starvation
response to starvation
cellular response to nutrient levels
cellular response to extracellular stimulus
lysosomal membrane
cellular response to external stimulus
response to nutrient levels
response to extracellular stimulus
positive regulation of intracellular signal transduction
positive regulation of signal transduction
cellular response to stress
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction