L-BMAA 500 to 750μM on day4 R04 exp185
Mechanism of Action
‘_-Methylamino-l-alanine, cyanobacterial neurotoxin, possible causative agent of ALS
- Class / Subclass 1: Environmental Stresses / Toxin
Technical Notes
Protein References
- PubChem Name: (S)-2-Amino-3-(methylamino)propanoic acid hydrochloride
- Synonyms: N/A
- CAS #: 16012-55-8
- PubChem CID: 51358333
- IUPAC: (2S)-2-amino-3-(methylamino)propanoic acid;hydrochloride
- INCHI Name: InChI=1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1
- INCHI Key: VDXYGASOGLSIDM-DFWYDOINSA-N
- Molecular Weight: 154.59
- Canonical SMILES: CNCC(C(=O)O)N.Cl
- Isomeric SMILES: CNC[C@@H](C(=O)O)N.Cl
- Molecular Formula: C4H11ClN2O2
Protein Supplier
- Supplier Name: BePharm Limited
- Catalog #: B216961
- Lot #: FC03-179
Protein Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C4H10N2O2 119.0815; found 119.07908
Dose Response Curve
- Platform ID: L-BMAA
- Min: -10.9269; Max: 5.5251
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 04
- Dose: 500-750µM
- Days of incubation: 8
- Doublings: 7.2
- Numbers of reads: 13378608
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 2/1 | Scores |
L-BMAA 500 to 750μM on day4 R04 exp185
L-BMAA 500 to 750μM on day4 R04 exp185 vs LJH685 5μM R02 exp73
L-BMAA 500 to 750μM on day4 R04 exp185 vs VHL-ligand-1 20μM R07 exp421
L-BMAA 500 to 750μM on day4 R04 exp185 vs proTAME 5μM R04 exp187
L-BMAA 500 to 750μM on day4 R04 exp185 vs PT-1 25μM R07 exp392
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471 vs L-BMAA 500 to 750μM on day4 R04 exp185
GSK343 3μM R03 exp124 vs L-BMAA 500 to 750μM on day4 R04 exp185
BN82002 4μM R07 exp340 vs L-BMAA 500 to 750μM on day4 R04 exp185
