NDUFB10

Gene Information

Official Symbol: NDUFB10
Official Name: N/ADH:ubiquinone oxidoreductase subunit B10
Aliases and Previous Symbols: N/A
Entrez ID: 4716
UniProt: O96000
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-2.64
Lapatinib 5μM R01 exp47	-1.83
FK-506 30μM R07 exp359	1.74
Arsenate 40μM R06 exp264	1.74
HMS-I2 5μM R06 exp287	1.77
Temozolomide 200μM R04 exp189	1.77
Thimerosal 0.85μM R08 exp529	1.79
Cerivastatin 0.15μM R05 exp226	1.81
Hydroxyurea 100μM R07 exp329	1.82
Chloroquine 32μM R08 exp470	1.83
Rapamycin 0.001μM R08 exp429	1.86
Chlorpromazine 10μM R07 exp344	1.91
Tubacin 1.6μM R07 exp416	1.91
UM0129480 7μM R02 exp85	1.97
Dynasore 10μM R04 exp180	2
Ribavirin 10 to 15μM on day4 R04 exp160	2.01
Artemisinin 50μM R08 exp450	2.09
Calcium Ionophore 0.4μM R07 exp342	2.12
Clomiphene 4.4μM R02 exp68	2.31
UM0125461 0.74μM R02 exp84	2.32
HMS-I2 10μM R06 exp288	2.52
Oligomycin-A 2μM R00 exp25	3.62

Gene	Correlation
GRSF1	0.637
NUBPL	0.613
ACAD9	0.608
NDUFA11	0.592
PDE12	0.589
MTO1	0.571
NDUFV2	0.563
NDUFB11	0.559
FASTKD2	0.556
NDUFB9	0.552
NDUFS2	0.543
NDUFB7	0.537
NDUFA1	0.537
ERAL1	0.536
MTIF2	0.536
NDUFC1	0.535
CHCHD1	0.533
NDUFAF3	0.528
GTPBP8	0.525
NDUFA2	0.519
CARS2	0.515
NDUFAF1	0.514
TIMMDC1	0.51
ECSIT	0.509
PET117	0.508
NDUFS8	0.506
NDUFAF6	0.5
SFXN4	0.5
SSBP1	0.498
NDUFB6	0.496
NDUFA10	0.496
NDUFB2	0.494
HMGXB3	0.491
MPV17L2	0.49
RMND1	0.489
NSUN4	0.488
NDUFA9	0.488
TFB1M	0.487
NDUFC2	0.482
NDUFB4	0.48
NDUFAF7	0.479
XPNPEP3	0.478
MALSU1	0.476
NDUFS5	0.474
FOXRED1	0.473
NDUFA8	0.469
MTRF1L	0.466
GTPBP10	0.463
MRPL17	0.461
NDUFS3	0.461
MRPL28	0.46
MRPL1	0.454
NDUFS7	0.454
PREPL	0.452
C1QBP	0.448
DDX28	0.448
MRPS18B	0.448
NDUFB5	0.447
NDUFA3	0.447
NDUFA6	0.444
TMEM261	0.441
MCAT	0.44
TSFM	0.439
METTL17	0.435
RTN4IP1	0.434
NDUFAF5	0.431
PET112	0.429
NDUFV1	0.429
RNMTL1	0.428
MRPL45	0.426
ICT1	0.425
MRPL3	0.423
GFM2	0.416
POLG2	0.415
NDUFS1	0.411
MIPEP	0.411
RPUSD3	0.411
PTCD3	0.41
NDUFB8	0.41
GTPBP6	0.407
FTSJ2	0.406
CLPX	0.404
NARS2	0.402
AARS2	0.401
LARS2	0.4

Global Fraction of Cell Lines Where Essential: 75/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	2/28
bone	2/26
breast	4/33
central nervous system	2/56
cervix	1/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	6/16
kidney	3/21
liver	5/20
lung	9/75
lymphocyte	0/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	5/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 607
Expression level (log2 read counts): 5.74

Expression Distribution