ACSL4
Gene Information
- Official Symbol: ACSL4
- Official Name: acyl-CoA synthetase long chain family member 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 2182
- UniProt: O60488
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016].
- UniProt Summary: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
Pfam Domains GO Terms
Pfam Domains
| AMP-binding |
GO Terms
| arachidonate-CoA ligase activity |
| embryonic process involved in female pregnancy |
| decanoate-CoA ligase activity |
| very long-chain fatty acid-CoA ligase activity |
| mitochondria-associated endoplasmic reticulum membrane |
| long-chain fatty acid-CoA ligase activity |
| response to interleukin-15 |
| acyl-CoA ligase activity |
| long-chain fatty-acyl-CoA biosynthetic process |
| triglyceride biosynthetic process |
| neutral lipid biosynthetic process |
| acylglycerol biosynthetic process |
| long-chain fatty-acyl-CoA metabolic process |
| dendritic spine development |
| fatty-acyl-CoA biosynthetic process |
| fatty-acyl-CoA metabolic process |
| acyl-CoA biosynthetic process |
| thioester biosynthetic process |
| peroxisomal membrane |
| ribonucleoside bisphosphate biosynthetic process |
| nucleoside bisphosphate biosynthetic process |
| purine nucleoside bisphosphate biosynthetic process |
| fatty acid transport |
| triglyceride metabolic process |
| lipid droplet |
| fatty acid derivative biosynthetic process |
| thioester metabolic process |
| acyl-CoA metabolic process |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| dendrite development |
| long-chain fatty acid metabolic process |
| nucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| ribonucleoside bisphosphate metabolic process |
| coenzyme biosynthetic process |
| monocarboxylic acid transport |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| mitochondrial outer membrane |
| fatty acid derivative metabolic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| female pregnancy |
| sulfur compound biosynthetic process |
| cofactor biosynthetic process |
| multi-multicellular organism process |
| response to nutrient |
| glycerolipid biosynthetic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| organic acid transport |
| carboxylic acid transport |
| lipid transport |
| purine ribonucleotide metabolic process |
| lipid localization |
| fatty acid metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| neuronal cell body |
| glycerolipid metabolic process |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic anion transport |
| response to nutrient levels |
| amide biosynthetic process |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| lipid biosynthetic process |
| anion transport |
| carbohydrate derivative biosynthetic process |
| embryo development ending in birth or egg hatching |
| neuron projection development |
| cellular amide metabolic process |
| neuron development |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| embryo development |
| multi-organism reproductive process |
| oxoacid metabolic process |
| neuron differentiation |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| lipid metabolic process |
| organic cyclic compound biosynthetic process |
| ion transport |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| ATP binding |
| generation of neurons |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| cell development |
| small molecule metabolic process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 4/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2533
- Expression level (log2 read counts): 6.68
Expression Distribution
ACSL4 Expression in NALM6 Cells: 6.68
