NDUFA8
Gene Information
- Official Symbol: NDUFA8
- Official Name: N/ADH:ubiquinone oxidoreductase subunit A8
- Aliases and Previous Symbols: N/A
- Entrez ID: 4702
- UniProt: P51970
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
- UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1905
- Expression level (log2 read counts): 4.7
NDUFA8 Expression in NALM6 Cells: 4.7
