RPL14
Gene Information
- Official Symbol: RPL14
- Official Name: ribosomal protein L14
- Aliases and Previous Symbols: N/A
- Entrez ID: 9045
- UniProt: P50914
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L14e |
GO Terms
| cytosolic large ribosomal subunit |
| ribosomal large subunit biogenesis |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| rRNA processing |
| mRNA catabolic process |
| rRNA metabolic process |
| RNA catabolic process |
| postsynaptic density |
| establishment of protein localization to membrane |
| ribosome biogenesis |
| cadherin binding |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| ncRNA processing |
| peptide biosynthetic process |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| protein localization to membrane |
| organic cyclic compound catabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| RNA processing |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| macromolecule catabolic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| SUPT6H | 0.515 |
| ORC1 | 0.497 |
| WDR43 | 0.497 |
| SMG7 | 0.486 |
| TFIP11 | 0.486 |
| CDC6 | 0.481 |
| DTL | 0.48 |
| CDC73 | 0.47 |
| NBPF10 | 0.469 |
| RPL17 | 0.468 |
| EXOSC3 | 0.466 |
| COPB1 | 0.465 |
| RPL7L1 | 0.465 |
| AKIRIN2 | 0.464 |
| ZFAND5 | 0.463 |
| PCF11 | 0.459 |
| RPS3A | 0.457 |
| HIST1H2BE | 0.453 |
| TBC1D3H | 0.452 |
| POLA2 | 0.448 |
| CEP192 | 0.448 |
| TBC1D3G | 0.447 |
| ANKLE2 | 0.445 |
| CKAP5 | 0.444 |
| C14orf93 | 0.443 |
| RPS28 | 0.442 |
| TOP1MT | 0.44 |
| POLR2A | 0.439 |
| COPB2 | 0.439 |
| VASN | 0.438 |
| PSMC1 | 0.437 |
| RPL6 | 0.435 |
| COPG1 | 0.435 |
| NOP16 | 0.434 |
| RRP15 | 0.434 |
| NUPL1 | 0.434 |
| DIDO1 | 0.433 |
| NIP7 | 0.433 |
| PSMA7 | 0.433 |
| TBC1D3F | 0.432 |
| ELMOD3 | 0.432 |
| RBM39 | 0.431 |
| ORC6 | 0.431 |
| RPS5 | 0.43 |
| TBC1D3 | 0.429 |
| RPL37A | 0.428 |
| SF3A3 | 0.428 |
| SNRNP70 | 0.427 |
| RPL34 | 0.427 |
| MYO1H | 0.427 |
| CBWD3 | 0.426 |
| RPL26 | 0.422 |
| PSMC6 | 0.422 |
| NSF | 0.421 |
| TBC1D3C | 0.421 |
| PSMB1 | 0.421 |
| PSMB4 | 0.42 |
| SF3A1 | 0.42 |
| PSMD11 | 0.418 |
| RPS2 | 0.416 |
| CBWD5 | 0.416 |
| ADRM1 | 0.415 |
| COPZ1 | 0.415 |
| RPS14 | 0.415 |
| CCNA2 | 0.414 |
| RFPL3 | 0.413 |
| HAP1 | 0.413 |
| RPS11 | 0.413 |
| TRAM1 | 0.412 |
| RAD51 | 0.412 |
| DDX56 | 0.412 |
| PPM1D | 0.411 |
| GOSR2 | 0.411 |
| RPS12 | 0.41 |
| NOL10 | 0.409 |
| TBC1D3I | 0.409 |
| SULT2B1 | 0.409 |
| C19orf53 | 0.409 |
| KCTD17 | 0.409 |
| TBC1D3E | 0.408 |
| TBC1D3L | 0.408 |
| TBC1D3K | 0.408 |
| RPL35 | 0.408 |
| NUP205 | 0.407 |
| MED17 | 0.407 |
| CGB2 | 0.406 |
| RIOK2 | 0.406 |
| GAR1 | 0.406 |
| IK | 0.405 |
| RPL30 | 0.404 |
| TWISTNB | 0.404 |
| RPS7 | 0.404 |
| AQR | 0.404 |
| LRR1 | 0.403 |
| TERF1 | 0.403 |
| CLN6 | 0.403 |
| EXOSC5 | 0.402 |
| CCDC64B | 0.402 |
| CBWD6 | 0.402 |
| ZNF106 | 0.401 |
| CDCA3 | 0.401 |
| INTS6 | 0.4 |
| SLC4A1 | 0.4 |
| TAF1 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 734/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 55/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 22/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 370
- Expression level (log2 read counts): 9.01
Expression Distribution
RPL14 Expression in NALM6 Cells: 9.01
