NDC80

Gene Information

Official Symbol: NDC80
Official Name: NDC80 kinetochore complex component
Aliases and Previous Symbols: N/A
Entrez ID: 10403
UniProt: O14777
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:9315664}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 7μM R03 exp135	-2.35
Atovaquone 15μM R08 exp451	-2.17
BI-6727 0.04μM R03 exp98	-1.72
TIC10 10μM R08 exp532	-1.7
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.71
DKK1 89ng/ml R08 exp477	1.73
Nicotinamide 1000μM R03 exp101	1.75
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.76
Isonicotinamide 500μM R03 exp129	1.81
Q15 2.7μM R02 exp79	1.83
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.85
NFN1 1μM R03 exp100	1.9
SGC0649 7μM R03 exp150	1.91
Rapamycin 1μM R00 exp29	1.93
RS-1 10μM R08 exp519	1.93
Nocodazole 0.02μM R00 exp23	1.99
L-74142 5μM R03 exp131	2.02
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.04
S-trityl-L-cysteine 0.5μM R05 exp243	2.07
Celastrol 0.12μM R05 exp225	2.16
NN-Diethyl-meta-toluamide 100μM R05 exp237	2.18
Cycloheximide 0.02μM R00 exp14	2.24
A-395N 10μM R05 exp219	2.27
EPZ-5676 30μM R05 exp233	2.27
Bafilomycin-A1 0.009μM R08 exp454	2.3
Bortezomib 0.005μM R00 exp6	2.32
BH1 1μM R04 exp169	2.38
Ethanol 0.003 R08 exp437	2.42
PFI-2 4μM R05 exp239	2.64
TRAIL 50ng/ml R00 exp36	2.72
DABN 2μM R00 exp16	3.12
LY2090314 0.003μM R08 exp499	3.27

Gene	Correlation
C14orf93	0.49
DTL	0.479
CDC73	0.469
CMYA5	0.467
NOP16	0.465
KRT78	0.454
RPS2	0.454
TBC1D3H	0.448
PSMC5	0.436
TBC1D3G	0.433
ATXN1	0.432
FAM160A1	0.428
ATP6AP1	0.427
VASN	0.425
TBC1D3I	0.423
MDM2	0.423
TBC1D3E	0.423
ANKLE2	0.422
TBC1D3L	0.422
TBC1D3K	0.422
TWISTNB	0.421
POLR2J3	0.42
TPX2	0.418
SRRM2	0.416
TRIM52	0.416
TOPBP1	0.416
XYLT2	0.414
NUPL1	0.413
TBC1D3F	0.412
SUPT5H	0.412
TBC1D3	0.412
LAD1	0.41
TICRR	0.41
PPFIA4	0.409
UQCRH	0.409
TBC1D3C	0.409
CCNA2	0.407
AAMP	0.407
S1PR4	0.407
DOCK6	0.405
PLK1	0.405
GOLGA8O	0.405
PAF1	0.403
LOC643669	0.402
SEC13	0.401
TCEB3CL2	0.4
PSMA6	0.4

Global Fraction of Cell Lines Where Essential: 721/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	11/13
fibroblast	1/1
gastric	15/16
kidney	20/21
liver	20/20
lung	73/75
lymphocyte	15/16
ovary	26/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 238
Expression level (log2 read counts): 6.05

Expression Distribution

Ndc80 complex
positive regulation of protein localization to kinetochore
condensed nuclear chromosome outer kinetochore
regulation of protein localization to kinetochore
positive regulation of spindle checkpoint
positive regulation of mitotic cell cycle spindle assembly checkpoint
condensed nuclear chromosome kinetochore
positive regulation of cell cycle checkpoint
attachment of mitotic spindle microtubules to kinetochore
regulation of mitotic spindle checkpoint
regulation of spindle checkpoint
regulation of mitotic cell cycle spindle assembly checkpoint
kinetochore organization
attachment of spindle microtubules to kinetochore
establishment of mitotic spindle orientation
regulation of cell cycle checkpoint
establishment of mitotic spindle localization
establishment of spindle orientation
establishment of spindle localization
mitotic metaphase plate congression
spindle localization
regulation of mitotic metaphase/anaphase transition
regulation of metaphase/anaphase transition of cell cycle
chromosome, centromeric region
metaphase plate congression
regulation of mitotic sister chromatid separation
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
establishment of chromosome localization
chromosome localization
mitotic spindle organization
regulation of sister chromatid segregation
kinetochore
condensed chromosome kinetochore
regulation of chromosome segregation
microtubule cytoskeleton organization involved in mitosis
mitotic sister chromatid segregation
establishment of cell polarity
sister chromatid segregation
mitotic nuclear division