UXT

Gene Information

Official Symbol: UXT
Official Name: ubiquitously expressed prefoldin like chaperone
Aliases and Previous Symbols: N/A
Entrez ID: 8409
UniProt: Q9UBK9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). {ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:11854421, ECO:0000269|PubMed:16221885, ECO:0000269|PubMed:17554592, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:17635584, ECO:0000269|PubMed:21307340, ECO:0000269|PubMed:21730289, ECO:0000269|PubMed:28106301}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
RNMT	0.548
ADSL	0.539
GMPPB	0.535
GTF3C3	0.523
TELO2	0.516
THG1L	0.51
ATXN10	0.51
UAP1	0.509
VRK1	0.506
MED4	0.504
RTCB	0.502
DPAGT1	0.499
ALG1	0.499
PMM2	0.495
UHRF1	0.49
GTF3C2	0.486
DDX20	0.485
EIF4E	0.48
RPP21	0.48
GPN2	0.479
YARS	0.477
NARS	0.476
ORAOV1	0.473
GFPT1	0.472
GNB1L	0.466
RPTOR	0.465
ERCC2	0.458
EPRS	0.458
SRP68	0.457
ALG13	0.456
ALG2	0.453
TTI2	0.452
TTI1	0.451
MED16	0.451
GEMIN8	0.45
GEMIN5	0.449
UTP23	0.449
CSNK2B	0.448
TRIAP1	0.447
OIP5	0.446
TTC4	0.446
PPCS	0.442
AARS	0.442
TSEN54	0.441
SRP14	0.439
CCDC101	0.438
GTF3C6	0.435
GEMIN7	0.434
RPE	0.431
NAE1	0.43
TBCB	0.428
POLR3H	0.425
CCT7	0.422
TXNL4B	0.421
SNAPC5	0.42
NSMCE1	0.419
TGS1	0.419
FNTA	0.419
TEN1	0.419
DR1	0.419
DOHH	0.418
TAF1A	0.417
DHPS	0.415
ALG14	0.412
ALG5	0.412
LAMTOR5	0.411
GTF3C4	0.41
RPN1	0.41
WDR92	0.41
TBCA	0.409
PPP4C	0.408
CHCHD4	0.406
EXOC4	0.405
TBCD	0.403
RPIA	0.401
DAD1	0.401

Global Fraction of Cell Lines Where Essential: 225/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	12/28
blood	4/26
bone	13/25
breast	9/30
central nervous system	10/49
cervix	1/4
colorectal	6/17
esophagus	7/11
fibroblast	0/1
gastric	3/14
kidney	3/18
liver	1/19
lung	24/72
lymphocyte	5/14
ovary	12/25
pancreas	7/22
peripheral nervous system	2/15
plasma cell	4/12
prostate	0/1
skin	2/20
soft tissue	2/7
thyroid	2/2
upper aerodigestive	17/22
urinary tract	15/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1008
Expression level (log2 read counts): 5.01

Expression Distribution

Screen	Score
CAY10603 0.55μM R08 exp467	-2.13
Celastrol 0.12μM R05 exp225	-1.83

gamma-tubulin complex
establishment of mitochondrion localization, microtubule-mediated
mitochondrion transport along microtubule
establishment of mitochondrion localization
beta-tubulin binding
negative regulation of G0 to G1 transition
regulation of G0 to G1 transition
mitochondrion localization
organelle transport along microtubule
centrosome cycle
transcription coregulator activity
microtubule organizing center organization
chromatin
spindle pole
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
actin filament binding
microtubule binding
transcription corepressor activity
microtubule-based movement
negative regulation of cell cycle process
establishment of organelle localization
cytoskeleton
chromatin binding
microtubule cytoskeleton organization
centrosome
negative regulation of cell cycle
organelle localization
microtubule-based process
regulation of cell cycle process
negative regulation of transcription by RNA polymerase II
apoptotic process
cell cycle process
programmed cell death
cell death
cytoskeleton organization
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription