Resveratrol 16μM R03 exp147 [The Human Chemical-Genetic Interaction Map Project]

Putative sirtuin activator, many other ascribed activities, analog of pterostilbene

Class / Subclass 1: Gene Regulation / Epigenetic Activator

Compound References

PubChem Name: Resveratrol
Synonyms: SRT 501; trans-Resveratrol
CAS #: 501-36-0
PubChem CID: 445154
IUPAC: 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
INCHI Name: InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
INCHI Key: LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Molecular Weight: 228.24
Canonical SMILES: C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
Isomeric SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O
Molecular Formula: C14H12O3

Compound Supplier

Supplier Name: Toronto Research Chemicals
Catalog #: R150000
Lot #: 2-ZNL-10-1

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C14H12O3 229.08592; found 229.086

Dose Response Curve

Platform ID: RESVERATROL
Min: 2.6734; Max: 95.8148

IC	Concentration (µM)
IC10	N/A
IC20	9.7877
IC30	14.8061
IC40	20.7871
IC50	28.3805
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 16µM
Days of incubation: 8
Doublings: 4.8
Numbers of reads: 12942673

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
12/4	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
ACSL4	-4.53	<0.01
GTPBP2	-3.79	<0.01
RNASEH2B	-3.08	<0.01
TKTL1	-3.06	<0.01
HGC6.3	-2.97	0.30
RECQL5	-2.95	0.01
RNASEH2A	-2.87	0.03
KPNA3	-2.83	0.02
KPNA4	-2.77	0.01
ADIPOR2	-2.76	0.01
GTPBP1	-2.72	0.03
RBM5	-2.66	0.02
KDSR	-2.55	0.03
OTUB1	-2.40	0.08
MKLN1	-2.39	0.06
ATP5J	-2.36	0.06
YWHAE	-2.35	0.06
MAEA	-2.34	0.06
RING1	-2.32	0.10
PPIL1	-2.32	0.16
RANBP1	-2.31	0.06
MAN2B1	-2.31	0.06
NEK5	-2.29	0.11
GLRX3	-2.26	0.08
CDKN2AIP	-2.25	0.08
CCDC111	-2.22	0.09
WDR26	-2.20	0.15
HIST1H3E	-2.19	0.10
SNF8	-2.19	0.16
TCF4	-2.18	0.23
SFXN4	2.17	0.19
USP37	2.18	0.25
PNISR	2.18	0.18
ZC3H7A	2.18	0.15
RBPJ	2.18	0.18
COPZ1	2.18	0.32
TCTE3	2.19	0.18
NRAS	2.20	0.14
AGMO	2.22	0.14
RBM7	2.22	0.24
CLEC2D	2.22	0.14
MAK16	2.24	0.18
FBXO48	2.25	0.13
BTBD9	2.26	0.21
MRPS7	2.27	0.27
OR3A2	2.29	0.15
SLFN11	2.32	0.10
GLRX5	2.33	0.18
RPL10	2.35	0.18
ZNF587B	2.42	0.12
DPH6	2.45	0.06
ZNF266	2.45	0.06
ZNF330	2.54	0.08
SESTD1	2.57	0.05
ASXL2	2.66	0.06
RBM25	2.74	0.07
GCN1L1	2.76	0.02
MCAT	2.77	0.02
PI4KB	2.88	0.02
PPP3R1	3.59	<0.01

Screen	Correlation	Plot
Rucaparib 6.5μM R08 exp520	0.052	View
Trimetrexate 0.03μM R08 exp535	0.051	View
Pterostilbene 16μM R02 exp78	0.123	View
MK-1775 0.32μM R02 exp75	0.079	View
Aphidicolin 0.4μM R08 exp440	0.076	View
Hydroxyurea 100μM R07 exp329	0.076	View
Diepoxybutane 3μM R07 exp354	0.057	View
Olaparib 4μM R08 exp512	0.055	View
Quercetin 20μM R08 exp517	0.054	View

Last modified: 2026/01/15 21:36
by 127.0.0.1