Demecolcine 0.03μM R05 exp228

Inhibits microtubule polymerization, a.k.a. colcemid

PubChem Name: Demecolcine
Synonyms: N/A
CAS #: 477-30-5
PubChem CID: 220401
IUPAC: (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
INCHI Name: InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
INCHI Key: NNJPGOLRFBJNIW-HNNXBMFYSA-N
Molecular Weight: 371.4
Canonical SMILES: CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
Isomeric SMILES: CN[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
Molecular Formula: C21H25NO5

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
45/9	Scores	View	View	View	View	View

Screen	Correlation	Plot
Mdivi-1 15μM R05 exp217	0.12	View
Vincristine 0.0005μM R04 exp190	0.113	View
Vinblastine 0.002μM R01 exp60	0.09	View
S-trityl-L-cysteine 0.5μM R05 exp243	0.083	View
Quercetin 20μM R08 exp517	0.082	View
UMK57 1μM R01 exp59	0.081	View
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	0.075	View
UM131593 0.2μM R03 exp106	0.068	View
Taxol 0.004μM R03 exp103	0.066	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.06	View
GSK461364A 0.005μM R03 exp125	0.058	View
UMK57 0.6μM R03 exp107	0.055	View
GSK626616 14μM R08 exp485	0.055	View
Sulforaphane 9μM R08 exp525	0.052	View
Epothilone-B 0.0015μM R05 exp231	0.052	View
Colchicine 0.009μM R05 exp215	0.189	View
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	0.182	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.123	View
BML-284 0.09μM R08 exp460	0.121	View
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	0.095	View
2-Methoxyestradiol 0.55μM R07 exp310	0.067	View
BI-6727 0.0125μM R03 exp97	0.058	View
BI-2536 0.0042μM R03 exp95	0.056	View

GO Term	Fold Change	Genes
negative regulation of microtubule polymerization	142.84	STMN1,MAPRE1,TBCD
outer kinetochore	90.22	NSL1,DSN1,SKA1
spindle pole	23.53	TACC3,ASPM,DLGAP5,SPAG5,NSL1,DSN1,MAPRE1
mitotic spindle	22.60	TACC3,ASPM,DLGAP5,SPAG5,TUBB4B,SKA1,MAPRE1
regulation of microtubule cytoskeleton organization	21.56	STMN1,TACC3,SPAG5,SKA1,MAPRE1,TBCD
mitotic sister chromatid segregation	21.01	DLGAP5,SPAG5,NSL1,DSN1,MAPRE1
sister chromatid segregation	20.41	DLGAP5,SPAG5,NSL1,DSN1,MAPRE1
spindle organization	19.93	STMN1,TACC3,ASPM,DLGAP5,SPAG5,MAPRE1
tubulin binding	14.05	KIF15,STMN1,DLGAP5,SPAG5,SKA1,VBP1,MAPRE1,TBCD,PDCD5
regulation of microtubule-based process	13.99	STMN1,TACC3,SPAG5,SKA1,MAPRE1,TBCD
spindle	13.80	KIF15,TACC3,ASPM,DLGAP5,SPAG5,TUBB4B,NSL1,DSN1,SKA1,MAPRE1
chromosome segregation	12.23	ASPM,DLGAP5,SPAG5,NSL1,DSN1,SKA1,MAPRE1
microtubule	10.53	KIF15,STMN1,ASPM,SPAG5,TUBB4B,SKA1,MAPRE1,TBCD
mitotic cell cycle	10.44	KIF15,STMN1,TACC3,DLGAP5,SPAG5,TUBB4B,NSL1,DSN1,SKA1,MAPRE1,TBCD
cell division	10.16	STMN1,TACC3,ASPM,PDS5B,SPAG5,NSL1,DSN1,SKA1,MAPRE1
microtubule cytoskeleton organization	8.48	STMN1,TACC3,ASPM,DLGAP5,SPAG5,TUBB4B,MAPRE1,TBCD
microtubule-based process	7.33	KIF15,STMN1,TACC3,ASPM,DLGAP5,SPAG5,TUBB4B,VBP1,MAPRE1,TBCD
cell cycle process	6.54	STMN1,TACC3,ASPM,DLGAP5,PDS5B,SPAG5,NSL1,DSN1,SKA1,MAPRE1
cytoskeletal protein binding	5.88	KIF15,STMN1,DLGAP5,SPAG5,SKA1,VEZT,VBP1,MAPRE1,TBCD,PDCD5