SNS-032 15μM R08 exp443

Inhibits CDK2, CDK7, CDK9

Class / Subclass 1: Cell Cycle / Cyclin Dependent Kinase Inhibitor
Class / Subclass 2: Signal Transduction / Kinase Inhibitor

Compound References

PubChem Name: Sns-032
Synonyms: BMS-387032
CAS #: 345627-80-7
PubChem CID: 3025986
IUPAC: N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
INCHI Name: InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
INCHI Key: OUSFTKFNBAZUKL-UHFFFAOYSA-N
Molecular Weight: 380.5
Canonical SMILES: CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
Isomeric SMILES: N/A
Molecular Formula: C17H24N4O2S2

Compound Supplier

Supplier Name: Ark Pharm Inc.
Catalog #: AK113734
Lot #: WG0165410-180313001

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H24N4O2S2 381.14134; found 381.14119

Dose Response Curve

Platform ID: SNS-032
Min: -14.2699; Max: 96.2471

IC	Concentration (µM)
IC10	N/A
IC20	17.2802
IC30	19.7073
IC40	22.2581
IC50	25.1188
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 08
Dose: 15µM
Days of incubation: 8
Doublings: -0.3
Numbers of reads: 19448233

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
7/45	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
POLR2L	-3.54	0.13
AURKB	-3.30	0.09
BCL2L1	-3.09	<0.01
NRAS	-3.06	<0.01
ATP13A1	-3.03	<0.01
GPR107	-2.93	<0.01
CDC73	-2.77	0.06
CDC42	-2.68	0.03
PSMA7	-2.64	0.11
RNF113A	-2.61	0.06
BCL2	-2.55	0.04
PPP1R12A	-2.55	0.04
VPS51	-2.54	0.09
TTK	-2.47	0.08
SMG7	-2.43	0.09
FHL2	-2.39	0.07
ZNF737	-2.39	0.09
ZFAND5	-2.39	0.07
CCDC116	-2.37	0.14
POLD3	-2.36	0.54
EXOSC1	-2.35	0.10
TBC1D3L	-2.34	0.29
POLA1	-2.34	0.29
WSB2	-2.33	0.08
TBC1D3K	-2.33	0.30
TBC1D3E	-2.32	0.30
TBC1D3I	-2.30	0.31
GCLC	-2.29	0.09
YRDC	-2.29	0.31
ARCN1	-2.27	0.12
SUZ12	2.54	0.01
CCDC101	2.54	0.01
PARL	2.55	0.02
TTI2	2.58	0.02
CYCS	2.61	0.01
MLST8	2.69	<0.01
CSNK2B	2.77	0.01
C10orf12	2.79	0.01
MED16	2.80	0.02
KCTD5	2.81	<0.01
TAZ	2.82	0.06
AHCYL1	2.84	<0.01
EPRS	2.86	0.03
FBXO11	2.87	<0.01
EZH2	2.91	<0.01
HCCS	2.91	0.01
ERCC2	2.97	0.09
ATP2B1	2.99	<0.01
STAU1	3.00	<0.01
TTI1	3.00	<0.01
GNB1L	3.03	<0.01
PHIP	3.05	<0.01
CASP9	3.33	<0.01
FAF2	3.60	<0.01
GMPPB	3.62	0.02
MARCH5	3.63	<0.01
VDAC2	3.84	<0.01
KMT2D	4.44	<0.01
APAF1	4.67	<0.01
BAK1	5.47	<0.01

Screen	Correlation	Plot
THZ1 0.06μM R08 exp531	0.146	View
Tanespimycin 14μM R08 exp527	0.077	View
Staurosporine 0.02μM R08 exp524	0.075	View
UM0129480 7μM R02 exp85	0.067	View
Vinblastine 0.2μM R03 exp108	0.064	View
Thimerosal 0.85μM R08 exp529	0.06	View
UM131593 0.2μM R03 exp106	0.057	View
Bleomycin 5μM R08 exp459	0.127	View
Mitomycin-C 0.06μM R08 exp503	0.117	View
Benzoate 20000μM R08 exp456	0.117	View
Doxorubicin 0.02μM R08 exp478	0.109	View
JQ1 0.8μM R08 exp435	0.108	View
Atovaquone 15μM R08 exp451	0.103	View
BI-2536 0.02μM R03 exp96	0.096	View
MS023 7μM R03 exp135	0.095	View
PU-H71 1μM R08 exp515	0.094	View
Etoposide 0.3μM R05 exp199	0.092	View
5-Fluorouracil 20μM R00 exp2	0.092	View
Aphidicolin 0.4μM R08 exp440	0.092	View
Olaparib 4μM R08 exp512	0.083	View
Rotenone 20μM R00 exp34	0.083	View
6-Thio-2-deoxyguanosine 2μM R06 exp259	0.081	View
GSK461364A 0.1μM R03 exp126	0.081	View
CR131-b 0.005μM R08 exp474	0.079	View
CI-1040 9.5μM R08 exp472	0.077	View
RO-3307 4.7μM R02 exp80	0.076	View
Hippuristanol 0.12μM R08 exp488	0.076	View
Ammonium tetrathiomolybdate 10μM R08 exp448	0.076	View
AICAR 240μM R03 exp116	0.075	View
CB-5083 0.4μM R08 exp468	0.071	View
Actinomycin-D 0.001μM R00 exp3	0.071	View
Hippuristanol 0.12μM R08 exp489 no dilution day6	0.071	View
MS023 2μM R03 exp134	0.068	View
Pimelic-diphenylamide-106 5μM R00 exp28	0.067	View
Artemisinin 50μM R08 exp450	0.066	View
MLN-4924 2μM R00 exp22	0.065	View
Etoposide 1μM R00 exp19	0.064	View
Hinokiflavone 12μM R08 exp487	0.064	View
AICAR 240μM R05 exp211	0.062	View
Quercetin 20μM R08 exp517	0.06	View
GSK626616 14μM R08 exp485	0.058	View
Dorsomorphin 5μM R07 exp357	0.058	View
Milciclib 2μM R08 exp502	0.055	View
BI-6727 0.04μM R03 exp98	0.053	View
2-Deoxy-D-glucose 800μM R05 exp214	0.053	View
42°C R08 exp539	0.052	View

GO Term	Fold Change	Genes
apoptosome	552.30	APAF1,CASP9
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	331.38	APAF1,CASP9,CYCS

Mechanism of Action

Technical Notes

Compound References

Compound Supplier

Compound Characterization

Dose Response Curve

Screen Summary

Screen Results