Cannabidiol 20μM R08 exp466
Mechanism of Action
Negative allosteric modulator of cannabinoid CB1 receptor
- Class / Subclass 1: Environmental Stresses / Psychoactive Drug
- Class / Subclass 2: Signal Transduction / GPCR Antagonist
Technical Notes
Compound References
- PubChem Name: Cannabidiol
- Synonyms: N/A
- CAS #: 13956-29-1
- PubChem CID: 644019
- IUPAC: 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol
- INCHI Name: InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1
- INCHI Key: QHMBSVQNZZTUGM-ZWKOTPCHSA-N
- Molecular Weight: 314.5
- Canonical SMILES: CCCCCC1=CC(=C(C(=C1)O)C2C=C(CCC2C(=C)C)C)O
- Isomeric SMILES: CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O
- Molecular Formula: C21H30O2
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: C175300
- Lot #: 9-RIT-154-2
Compound Characterization
- LCMS: Tr 1.38 min, m/z 315+ [M+H]+, 313- [M-H]-
Dose Response Curve
- Platform ID: CBD
- Min: -4.3129; Max: 99.8419
| IC | Concentration (µM) |
|---|---|
| IC10 | 7.8520 |
| IC20 | 10.4800 |
| IC30 | 12.6900 |
| IC40 | 14.8500 |
| IC50 | 17.1600 |
| IC60 | 19.8200 |
| IC70 | 23.1900 |
| IC80 | 28.0900 |
| IC90 | 37.4800 |
Screen Summary
- Round: 08
- Dose: 20µM
- Days of incubation: 8
- Doublings: 1.9
- Numbers of reads: 13942379
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 28/24 | Scores |
Cannabidiol 20μM R08 exp466
Cannabidiol 20μM R08 exp466 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
Cannabidiol 20μM R08 exp466 vs WYE-354 6μM R02 exp90
Cannabidiol 20μM R08 exp466 vs iCRT14 30μM R08 exp492
Cannabidiol 20μM R08 exp466 vs MK2206 4μM R08 exp504
Cannabidiol 20μM R08 exp466 vs Citral 75μM R06 exp275
Cannabidiol 20μM R08 exp466 vs Hippuristanol 0.12μM R08 exp488
Cannabidiol 20μM R08 exp466 vs Cryptotanshinone 12μM R05 exp227
Cannabidiol 20μM R08 exp466 vs UM0129480 7μM R02 exp85
Cannabidiol 20μM R08 exp466 vs QNZ 0.01μM R08 exp439
Cannabidiol 20μM R08 exp466 vs LJH685 50μM R08 exp433
Cannabidiol 20μM R08 exp466 vs Dorsomorphin 5μM R07 exp357
Cannabidiol 20μM R08 exp466 vs Chlorpromazine 10μM R07 exp344
Cannabidiol 20μM R08 exp466 vs Tubacin 1.6μM R07 exp416
Cannabidiol 20μM R08 exp466 vs FTY720 3μM R08 exp483
Cannabidiol 20μM R08 exp466 vs Ibrutinib 10μM R08 exp442
Cannabidiol 20μM R08 exp466 vs ZLN024 50μM R08 exp538
Cannabidiol 13μM R08 exp465 vs Cannabidiol 20μM R08 exp466
BVD-523 15μM R02 exp67 vs Cannabidiol 20μM R08 exp466
Bisphenol A 100μM R06 exp269 vs Cannabidiol 20μM R08 exp466
CAY10603 0.55μM R08 exp467 vs Cannabidiol 20μM R08 exp466
CB-5083 0.4μM R08 exp468 vs Cannabidiol 20μM R08 exp466
BS-181 20μM R08 exp461 vs Cannabidiol 20μM R08 exp466
All-trans-Retinoic-Acid 40μM R07 exp334 vs Cannabidiol 20μM R08 exp466
