Milciclib 2μM R08 exp502

Inhibits CDK2, also TRKA, CDK1, CDK4

PubChem Name: Milciclib
Synonyms: PHA-848125
CAS #: 802539-81-7
PubChem CID: 16718576
IUPAC: N,1,4,4-tetramethyl-8-[4-(4-methylpiperazin-1-yl)anilino]-5H-pyrazolo[4,3-h]quinazoline-3-carboxamide
INCHI Name: InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)
INCHI Key: RXZMYLDMFYNEIM-UHFFFAOYSA-N
Molecular Weight: 460.6
Canonical SMILES: CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C
Isomeric SMILES: N/A
Molecular Formula: C25H32N8O

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
23/45	Scores	View	View	View	View	View

Screen	Correlation	Plot
Staurosporine 0.02μM R08 exp524	0.101	View
RO-3307 4.7μM R02 exp80	0.071	View
UM0129480 7μM R02 exp85	0.066	View
Palbociclib 1μM R07 exp382	0.065	View
PU-H71 1μM R08 exp515	0.061	View
TIC10 10μM R08 exp532	0.06	View
UMK57 1μM R01 exp59	0.058	View
Thimerosal 0.85μM R08 exp529	0.056	View
SNS-032 15μM R08 exp443	0.055	View
Tanespimycin 14μM R08 exp527	0.055	View
Mitomycin-C 0.06μM R08 exp503	0.055	View
iCRT14 30μM R08 exp492	0.053	View
JQ1 0.8μM R08 exp435	0.091	View
Dorsomorphin 5μM R07 exp357	0.088	View
CB-5083 0.4μM R08 exp468	0.083	View
BVD-523 15μM R02 exp67	0.079	View
Hippuristanol 0.12μM R08 exp489 no dilution day6	0.073	View
GSK626616 14μM R08 exp485	0.068	View
BML-284 0.09μM R08 exp460	0.067	View
MS023 2μM R03 exp134	0.067	View
Hippuristanol 0.12μM R08 exp488	0.065	View
Lead acetate 2000μM R08 exp497	0.065	View
LY2090314 0.003μM R08 exp499	0.065	View
Aphidicolin 0.4μM R08 exp440	0.064	View
LY2090314 0.003μM R08 exp500 no dilution day6	0.064	View
Erlotinib 10μM R05 exp216	0.063	View
2-Deoxy-D-glucose 800μM R05 exp214	0.06	View
FK-506 30μM R07 exp359	0.06	View
Lead acetate 2000μM R08 exp498 no dilution day6	0.06	View
∆-9-Tetrahydrocannabinol 30μM R08 exp445	0.059	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.057	View
Bleomycin 5μM R08 exp459	0.057	View
Arsenate 40μM R06 exp264	0.054	View
MS023 7μM R03 exp135	0.054	View
6-Thio-2-deoxyguanosine 2μM R06 exp259	0.052	View
Actinomycin-D 0.001μM R00 exp3	0.051	View
Mdivi-1 15μM R05 exp217	0.051	View
Doxorubicin 0.02μM R08 exp478	0.051	View