DHX30

Entrez Summary: N/A
UniProt Summary: Plays an important role in the assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (PubMed:18063578). {ECO:0000250|UniProtKB:Q5BJS0, ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:25683715}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial large ribosomal subunit assembly
mitochondrial ribosome assembly
G-quadruplex RNA binding
ribonucleoprotein granule
3-5 RNA helicase activity
ribosomal large subunit assembly
mitochondrial nucleoid
DNA helicase activity
RNA helicase activity
ribosome assembly
double-stranded RNA binding
ribosomal large subunit biogenesis
DNA duplex unwinding
DNA geometric change
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
DNA conformation change
ribosome biogenesis
chromatin binding
ribonucleoprotein complex biogenesis
organelle assembly
cellular protein-containing complex assembly
central nervous system development
chromosome organization
mitochondrion
RNA binding
ATP binding
protein-containing complex assembly
protein-containing complex subunit organization