MRPL13

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 25/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	4/33
central nervous system	1/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	4/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	1.75
Thimerosal 0.85μM R08 exp529	1.83
Taxol 0.004μM R03 exp103	1.86
GSK-J4 1.5μM R08 exp441	1.95

mitochondrial ribosome
ribosome
mitochondrial large ribosomal subunit
mitochondrial translational termination
mitochondrial translational elongation
translational termination
mitochondrial translation
translational elongation
negative regulation of translation
cellular protein complex disassembly
mitochondrial gene expression
negative regulation of cellular amide metabolic process
mRNA binding
structural constituent of ribosome
protein-containing complex disassembly
regulation of translation
translation
mitochondrial inner membrane
cellular component disassembly
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
mitochondrion
negative regulation of cellular macromolecule biosynthetic process
RNA binding
organonitrogen compound biosynthetic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
negative regulation of gene expression
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression