PDAP1

Entrez Summary: The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010].
UniProt Summary: Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rifampicin 10μM R00 exp32	-2.46
BH1 1μM R04 exp169	-2.45
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.42
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.34
Vemurafenib 6.6μM R02 exp89	-2.27
I-BRD9 4μM R07 exp365	-2.21
TRAIL 5ng/ml R00 exp35	-2.19
Golgicide-A 4μM R03 exp122	-2.17
Clomiphene 4.4μM R02 exp68	-2.14
proTAME 5μM R04 exp187	-2.12
Chloroquine 32μM R08 exp470	-2.06
BI-D1870 2μM R04 exp162	-2.03
Thalidomide 20μM R07 exp406	-1.98
Dynasore 10μM R04 exp180	-1.93
Wortmannin 0.5μM R00 exp37	-1.86
Wortmannin 5μM R00 exp38	-1.83
Cisplatin 0.35μM R06 exp273	-1.79
Trichostatin-A 0.06μM R07 exp415	-1.79
SGC0946 7μM R03 exp151	-1.75
TRAIL 50ng/ml R00 exp36	-1.74
Ethanol 0.003 R08 exp437	-1.73
Fluvastatin 2.2μM R06 exp282	-1.73
3-Bromopyruvate 7μM R04 exp175	-1.71
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.71
Epothilone-B 0.0015μM R05 exp231	-1.71
Vemurafenib 6.6μM R08 exp434	-1.71
Mdivi-1 15μM R05 exp217	1.94
Deguelin 0.15μM R05 exp209	2.05
Nocodazole 0.2μM R02 exp64	2.11

Global Fraction of Cell Lines Where Essential: 462/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	17/28
blood	20/28
bone	15/26
breast	17/33
central nervous system	28/56
cervix	1/4
colorectal	15/17
esophagus	4/13
fibroblast	1/1
gastric	9/16
kidney	15/21
liver	17/20
lung	49/75
lymphocyte	10/16
ovary	10/26
pancreas	18/24
peripheral nervous system	11/16
plasma cell	5/15
prostate	1/1
skin	18/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	20/29
uterus	3/5

Expression Distribution

ficolin-1-rich granule lumen
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
secretion by cell
export from cell
cell activation
immune effector process
secretion
RNA binding
immune response
extracellular region
vesicle-mediated transport