TBCD

Entrez Summary: Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10μM R01 exp52	-3.03
Demecolcine 0.03μM R05 exp228	-2.64
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.55
Mubritinib 0.2μM R02 exp65	-2.43
Nifuroxazide 1μM R01 exp51	-2.32
B02 10μM R08 exp453	-2.26
Mubritinib 0.2μM R01 exp48	-2.2
Docetaxel 0.002μM R01 exp45	-2.17
BRD2 inhibitor II 20μM R07 exp341	-2.15
2-Methoxyestradiol 0.2μM R01 exp40	-2.13
Rapamycin 2μM plus FK-506 5μM R07 exp308	-2.08
Vincristine 0.0005μM R04 exp190	-2.04
Sulforaphane 9μM R08 exp525	-2.01
UM131593 0.1μM R01 exp58	-2
Radicicol 0.16μM R05 exp242	-1.99
Vinblastine 0.002μM R01 exp60	-1.92
CAY10603 0.55μM R08 exp467	-1.86
BAY-598 4μM R05 exp220	-1.85
Genistein 15μM R07 exp360	-1.85
GSK-J4 1-1.25μM to day4 R07 exp363	-1.82
Thimerosal 0.85μM R08 exp529	-1.82
UM0131023 0.05μM R05 exp248	-1.82
Nicotinamide 2000μM R01 exp50	-1.81
UM0011500 5μM R05 exp245	-1.81
Deguelin 0.15μM R05 exp209	-1.78
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.77
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.74
AICAR 240μM R05 exp211	-1.73
Zebularine 20μM R07 exp423	-1.73
Chlorpromazine 10μM R07 exp344	-1.7

Global Fraction of Cell Lines Where Essential: 449/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	20/28
blood	18/28
bone	19/26
breast	18/33
central nervous system	39/56
cervix	3/4
colorectal	10/17
esophagus	8/13
fibroblast	1/1
gastric	10/16
kidney	7/21
liver	11/20
lung	42/75
lymphocyte	12/16
ovary	13/26
pancreas	10/24
peripheral nervous system	11/16
plasma cell	8/15
prostate	1/1
skin	9/24
soft tissue	8/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	18/29
uterus	3/5

Expression Distribution

post-chaperonin tubulin folding pathway
tubulin complex assembly
negative regulation of microtubule polymerization
adherens junction assembly
bicellular tight junction assembly
negative regulation of microtubule polymerization or depolymerization
tight junction assembly
beta-tubulin binding
tight junction organization
apical junction assembly
regulation of microtubule polymerization
lateral plasma membrane
negative regulation of cell-substrate adhesion
adherens junction
negative regulation of protein polymerization
regulation of microtubule polymerization or depolymerization
adherens junction organization
chaperone binding
cell-cell junction assembly
bicellular tight junction
negative regulation of protein complex assembly
negative regulation of supramolecular fiber organization
cell-cell junction organization
negative regulation of cytoskeleton organization
cell junction assembly
regulation of microtubule cytoskeleton organization
regulation of cell-substrate adhesion
cell junction organization
regulation of microtubule-based process
regulation of protein polymerization
protein folding
negative regulation of cell adhesion
GTPase activator activity
microtubule
regulation of supramolecular fiber organization
negative regulation of organelle organization
positive regulation of GTPase activity
cell morphogenesis involved in neuron differentiation
regulation of protein complex assembly
microtubule cytoskeleton organization