SCAF1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-3.2
Dorsomorphin 5μM R07 exp357	-2.72
GSK-J4 1.5μM R08 exp441	-2.65
MS023 7μM R03 exp135	-2.14
Nocodazole 0.2μM R00 exp24	-1.93
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.85
CR131-b 0.005μM R08 exp474	-1.72
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.71
Lead acetate 990μM R08 exp496	1.73
CCCP 1μM R00 exp11	1.8
Chloramphenicol 20μM R00 exp13	1.8
Doxycycline 10μM R00 exp18	1.84
Metformin 100 to 150μM on day4 R04 exp170	1.84
Bortezomib 0.005μM R00 exp6	1.85
Colchicine 0.009μM R05 exp215	1.87
Pyrazinamide 100μM R08 exp516	1.95
S-trityl-L-cysteine 0.5μM R05 exp243	1.96
Rifampicin 10μM R00 exp32	1.99
Nocodazole 0.02μM R00 exp23	2.19
Geldanamycin 0.01μM R05 exp235	2.4
ABT-702 5μM R06 exp261	2.55
TRAIL 5ng/ml R00 exp35	2.55
Demecolcine 0.03μM R05 exp228	2.66
Cycloheximide 0.2μM R00 exp15	2.79
Chloramphenicol 2μM R00 exp12	2.82
AICAR 240μM R05 exp211	3.13

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution