SF3A3

Gene Information

Official Symbol: SF3A3
Official Name: splicing factor 3a subunit 3
Aliases and Previous Symbols: N/A
Entrez ID: 10946
UniProt: Q12874
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinblastine 0.015μM R05 exp208	-1.9
42°C R08 exp539	-1.82
Actinomycin-D 0.01μM R00 exp4	-1.77
IU1-C 25μM R04 exp183	1.7
CHIR-124 0.04μM R06 exp272	1.71
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.72
Salubrinal 20μM R07 exp399	1.76
All-trans-Retinoic-Acid 8μM R07 exp333	1.79
Radicicol 0.16μM R05 exp242	1.82
A-395 10μM R05 exp218	1.84
VE-822 0.04μM R06 exp300	1.89
Dexamethasone 0.006μM R07 exp351	2.14
Thalidomide 20μM R07 exp406	2.25

Gene	Correlation
DTL	0.542
VASN	0.527
AKIRIN2	0.503
TCEB3C	0.497
CHD4	0.495
NARFL	0.495
PAF1	0.493
KIAA0947	0.489
RPL35	0.485
POLR2A	0.483
WDR75	0.482
ORC6	0.481
PSMB2	0.476
MT1E	0.476
MYLK3	0.475
INTS6	0.469
SUPT6H	0.468
PRIM1	0.468
GID4	0.468
SF3A2	0.467
TCEB3CL2	0.466
KCTD17	0.466
PSMB4	0.461
RPS2	0.461
ORC1	0.46
C1QTNF9B	0.459
COPG1	0.459
NBPF10	0.458
LRR1	0.457
TICRR	0.457
SNRNP70	0.457
NPIPB5	0.455
RRP12	0.453
NOL10	0.452
BYSL	0.451
BRD2	0.451
TCEB3CL	0.45
CLN6	0.448
UTP20	0.448
NUFIP2	0.447
PAN3	0.447
RBM39	0.446
RPS12	0.445
DIMT1	0.444
CDC6	0.443
EXD1	0.443
EIF4A3	0.443
C14orf93	0.442
TSG101	0.442
COPB1	0.442
CDC73	0.441
ZNF106	0.44
PPM1D	0.44
CEP192	0.44
CGB2	0.44
RNF113A	0.439
RPS5	0.435
PSMA6	0.435
HNRNPC	0.432
GOLGA6A	0.432
POLR1A	0.431
INTS5	0.431
PSMD11	0.431
PSMB1	0.431
CBWD3	0.429
SEC13	0.429
NOP16	0.429
RPL14	0.428
DDTL	0.427
PSMA7	0.426
RRP15	0.426
TFIP11	0.426
TP53TG3	0.425
CBWD6	0.425
TP53TG3C	0.425
TERF2	0.425
TP53TG3B	0.425
OSBP	0.424
SLC6A17	0.424
COPA	0.424
SUPT5H	0.424
CDT1	0.423
CKAP5	0.423
ATP6V1A	0.422
CTAGE4	0.421
PSMD7	0.421
TBC1D3C	0.42
TBC1D3G	0.42
UBAP1	0.42
RPS3A	0.419
GOLGA6L6	0.419
CBWD5	0.419
RPS19	0.418
RFFL	0.417
MFSD12	0.417
SF3A1	0.416
NUP160	0.415
TBC1D3H	0.414
RIOK2	0.412
ATP6V1C1	0.412
POLA2	0.412
NAPA	0.411
GNB3	0.411
RPL6	0.41
TWISTNB	0.408
PSMD3	0.408
ANKLE2	0.408
CHAF1A	0.407
TFRC	0.407
CDCA3	0.407
OR10G3	0.407
RFXANK	0.407
PCF11	0.407
ARCN1	0.407
ATXN1	0.407
RRN3	0.406
NOL12	0.406
INTS8	0.406
RPS3	0.405
SLC4A1	0.405
ISCU	0.404
DHX38	0.404
PSMD1	0.404
RBBP5	0.404
NCL	0.403
TBC1D3F	0.403
ESF1	0.402
CTR9	0.402
SF3B1	0.402
CACTIN	0.402
SSH2	0.402
TSPY1	0.402
ISY1	0.402
PSMC2	0.401
PRPF8	0.401
CYB561A3	0.401
ZNF655	0.4
CACNA1A	0.4
ZNF830	0.4
SAP30BP	0.4

Global Fraction of Cell Lines Where Essential: 675/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	26/28
bone	20/26
breast	32/33
central nervous system	51/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	13/16
kidney	18/21
liver	17/20
lung	67/75
lymphocyte	16/16
ovary	22/26
pancreas	23/24
peripheral nervous system	13/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	25/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 218
Expression level (log2 read counts): 7.48

Expression Distribution