UBE2J1
Gene Information
- Official Symbol: UBE2J1
- Official Name: ubiquitin conjugating enzyme E2 J1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51465
- UniProt: Q9Y385
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| UQ con |
GO Terms
| negative regulation of retrograde protein transport, ER to cytosol |
| negative regulation of protein exit from endoplasmic reticulum |
| regulation of retrograde protein transport, ER to cytosol |
| negative regulation of ERAD pathway |
| regulation of protein exit from endoplasmic reticulum |
| regulation of ERAD pathway |
| regulation of tumor necrosis factor biosynthetic process |
| protein N-linked glycosylation via asparagine |
| peptidyl-asparagine modification |
| ubiquitin conjugating enzyme activity |
| negative regulation of intracellular protein transport |
| negative regulation of response to endoplasmic reticulum stress |
| negative regulation of proteasomal protein catabolic process |
| negative regulation of intracellular transport |
| ubiquitin-dependent ERAD pathway |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| protein N-linked glycosylation |
| regulation of response to endoplasmic reticulum stress |
| negative regulation of cellular protein catabolic process |
| ERAD pathway |
| regulation of cytokine biosynthetic process |
| negative regulation of cellular protein localization |
| negative regulation of protein catabolic process |
| regulation of tumor necrosis factor production |
| spermatid development |
| regulation of tumor necrosis factor superfamily cytokine production |
| spermatid differentiation |
| negative regulation of protein transport |
| regulation of proteasomal protein catabolic process |
| negative regulation of establishment of protein localization |
| regulation of proteolysis involved in cellular protein catabolic process |
| regulation of intracellular protein transport |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| germ cell development |
| response to endoplasmic reticulum stress |
| protein glycosylation |
| macromolecule glycosylation |
| glycosylation |
| ubiquitin protein ligase binding |
| negative regulation of catabolic process |
| glycoprotein biosynthetic process |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| regulation of intracellular transport |
| negative regulation of proteolysis |
| cellular process involved in reproduction in multicellular organism |
| regulation of protein catabolic process |
| glycoprotein metabolic process |
| negative regulation of transport |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| regulation of cellular protein localization |
| modification-dependent macromolecule catabolic process |
| spermatogenesis |
| male gamete generation |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| carbohydrate derivative biosynthetic process |
| developmental process involved in reproduction |
| protein catabolic process |
| protein ubiquitination |
| gamete generation |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| protein modification by small protein conjugation |
| multicellular organismal reproductive process |
| sexual reproduction |
| regulation of cellular catabolic process |
| multicellular organism reproduction |
| peptidyl-amino acid modification |
| cellular macromolecule catabolic process |
| regulation of cellular localization |
| endoplasmic reticulum membrane |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| multi-organism reproductive process |
| response to organonitrogen compound |
| regulation of protein localization |
| carbohydrate derivative metabolic process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| proteolysis |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| regulation of response to stress |
| ATP binding |
| negative regulation of response to stimulus |
| cell development |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| DNAJC3 | 0.665 |
| MANF | 0.619 |
| DERL2 | 0.602 |
| UBE2G2 | 0.582 |
| ALG5 | 0.556 |
| UFM1 | 0.554 |
| DNAJB11 | 0.547 |
| PMM2 | 0.527 |
| C1orf27 | 0.526 |
| UFC1 | 0.523 |
| DERL1 | 0.505 |
| UBA5 | 0.501 |
| UFSP2 | 0.483 |
| ALG9 | 0.481 |
| HARS | 0.48 |
| ENY2 | 0.479 |
| XPO6 | 0.477 |
| TMEM41B | 0.477 |
| TMED10 | 0.476 |
| SEC62 | 0.475 |
| RPE | 0.47 |
| TAZ | 0.468 |
| AUP1 | 0.462 |
| DPAGT1 | 0.462 |
| PPP2R3C | 0.461 |
| ALG1 | 0.46 |
| VMP1 | 0.456 |
| RPTOR | 0.444 |
| OPA1 | 0.442 |
| DAD1 | 0.441 |
| UBE2K | 0.441 |
| IRF2BP2 | 0.437 |
| TRMT5 | 0.433 |
| ALG6 | 0.433 |
| FAF2 | 0.431 |
| SEC63 | 0.431 |
| RNMT | 0.43 |
| ROMO1 | 0.428 |
| TRIAP1 | 0.425 |
| HSPD1 | 0.423 |
| CCDC101 | 0.423 |
| DDRGK1 | 0.421 |
| UFL1 | 0.42 |
| STT3A | 0.419 |
| GMPPB | 0.419 |
| OS9 | 0.418 |
| OTUD5 | 0.416 |
| CRLS1 | 0.415 |
| BAP1 | 0.412 |
| PLAA | 0.411 |
| ALG2 | 0.411 |
| GTF3C4 | 0.408 |
| RPS6KB1 | 0.407 |
| OST4 | 0.406 |
| ATP5J | 0.406 |
| KCMF1 | 0.406 |
| GTF3C2 | 0.405 |
| RAD1 | 0.405 |
| MLLT1 | 0.404 |
| CBFB | 0.403 |
| THOC6 | 0.402 |
| SRP14 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3517
- Expression level (log2 read counts): 7.7
Expression Distribution
UBE2J1 Expression in NALM6 Cells: 7.7
