WDR43
Gene Information
- Official Symbol: WDR43
- Official Name: WD repeat domain 43
- Aliases and Previous Symbols: N/A
- Entrez ID: 23160
- UniProt: Q15061
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751}.
Pfam Domains GO Terms
Pfam Domains
| WD40 |
| Utp12 |
GO Terms
| positive regulation of rRNA processing |
| positive regulation of ribosome biogenesis |
| regulation of rRNA processing |
| regulation of ribosome biogenesis |
| positive regulation of transcription by RNA polymerase I |
| regulation of transcription by RNA polymerase I |
| fibrillar center |
| rRNA processing |
| rRNA metabolic process |
| ribosome biogenesis |
| ncRNA processing |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| positive regulation of cellular component biogenesis |
| nucleolus |
| RNA processing |
| regulation of cellular component biogenesis |
| RNA binding |
| positive regulation of transcription, DNA-templated |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| SMG7 | 0.509 |
| RPL14 | 0.497 |
| RPS19BP1 | 0.496 |
| C1QTNF9B | 0.493 |
| TCEB3CL2 | 0.488 |
| POLA2 | 0.484 |
| CDC45 | 0.482 |
| TCEB3CL | 0.481 |
| TBC1D3H | 0.479 |
| PSMC6 | 0.477 |
| PSMD11 | 0.476 |
| ATP13A1 | 0.475 |
| ZFAND5 | 0.474 |
| RPL35 | 0.469 |
| SUPT6H | 0.469 |
| PCF11 | 0.467 |
| NOL10 | 0.465 |
| DTL | 0.462 |
| RPL34 | 0.461 |
| TCEB3C | 0.461 |
| TBC1D3G | 0.456 |
| DDTL | 0.456 |
| CBWD3 | 0.456 |
| ZNF106 | 0.455 |
| COPE | 0.451 |
| COPB1 | 0.451 |
| CDCA3 | 0.448 |
| PSMB1 | 0.448 |
| RRP15 | 0.447 |
| CBWD5 | 0.447 |
| RAD51 | 0.446 |
| RPS12 | 0.444 |
| MED29 | 0.443 |
| PSMD1 | 0.442 |
| POLE | 0.441 |
| PSMA6 | 0.44 |
| TBC1D3F | 0.44 |
| CCDC64B | 0.439 |
| PAN2 | 0.438 |
| PSMC1 | 0.435 |
| SEL1L | 0.433 |
| RRP7A | 0.432 |
| TICRR | 0.432 |
| RPS28 | 0.432 |
| RPS3 | 0.432 |
| SNRPA1 | 0.432 |
| NUP43 | 0.43 |
| MBTD1 | 0.429 |
| VASN | 0.429 |
| RRN3 | 0.429 |
| TERF2 | 0.429 |
| PSMC2 | 0.428 |
| PSMB2 | 0.428 |
| COPB2 | 0.426 |
| CBWD6 | 0.426 |
| NOL12 | 0.426 |
| TWISTNB | 0.426 |
| TBC1D3C | 0.425 |
| CCDC94 | 0.424 |
| BCL2L1 | 0.424 |
| IK | 0.423 |
| ORC6 | 0.422 |
| ADRM1 | 0.419 |
| PAN3 | 0.419 |
| OGFR | 0.418 |
| PSMD7 | 0.417 |
| NPIPB5 | 0.416 |
| ORC1 | 0.415 |
| SSH2 | 0.415 |
| CHCHD3 | 0.415 |
| RPS3A | 0.415 |
| UPF1 | 0.414 |
| HIVEP3 | 0.413 |
| KPNB1 | 0.413 |
| SMG5 | 0.413 |
| NBPF10 | 0.413 |
| TBC1D3 | 0.41 |
| RPL38 | 0.408 |
| POLR2A | 0.407 |
| PSMD13 | 0.407 |
| PSMB4 | 0.406 |
| NIP7 | 0.406 |
| PSMD3 | 0.406 |
| NOP16 | 0.406 |
| SART1 | 0.405 |
| PSMD6 | 0.405 |
| PSMC4 | 0.404 |
| CHD4 | 0.404 |
| RAD21 | 0.404 |
| IGFN1 | 0.404 |
| TOP1MT | 0.404 |
| LAD1 | 0.403 |
| NUP153 | 0.403 |
| RNPC3 | 0.403 |
| MDM2 | 0.403 |
| RPL7L1 | 0.402 |
| CTAGE4 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 738/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 27/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 28
- Expression level (log2 read counts): 7.35
Expression Distribution
WDR43 Expression in NALM6 Cells: 7.35
