PMVK

Gene Information

Official Symbol: PMVK
Official Name: phosphomevalonate kinase
Aliases and Previous Symbols: N/A
Entrez ID: 10654
UniProt: Q15126
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LJH685 5μM R02 exp73	-2.2
CVT-10216 0.1μM R06 exp278	-2.09
VE-822 0.04μM R06 exp300	-2.09
UNC2400 2μM R03 exp156	-1.95
Etoposide 10μM R00 exp20	-1.85
proTAME 5μM R04 exp187	-1.85
SGC0649 7μM R03 exp150	-1.83
HMS-I2 1μM R06 exp286	-1.74
Metformin 100 to 150μM on day4 R04 exp170	-1.74
JQ1 0.01μM R03 exp130	-1.72
GSK-LSD1 10μM R03 exp123	-1.7
Artemisinin 50μM R08 exp450	1.7
Aphidicolin 0.4μM R08 exp440	1.71
INK128 0.2μM R02 exp70	1.71
Cannabidiol 20μM R08 exp466	1.74
NMS-873 0.07μM R07 exp380	1.74
Thimerosal 0.85μM R08 exp529	1.78
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.8
Arsenate 40μM R06 exp264	1.8
Milciclib 2μM R08 exp502	1.83
KU-0063794 3.8μM R02 exp71	1.86
CR131-b 0.005μM R08 exp474	1.89
5-Azacytidine 2μM R07 exp330	1.91
Rotenone 0.07μM R08 exp431	1.94
Cytochalasin-B 5μM R07 exp349	1.99
Arsenic trioxide 60μM R08 exp449	2.06
Quercetin 20μM R08 exp517	2.06
Chloramphenicol 20μM R00 exp13	2.09
Centrinone 0.5μM R07 exp343	2.11
Amiloride 100μM R08 exp447	2.23
Salubrinal 20μM R07 exp399	2.24
Senexin-A 25μM R07 exp400	2.39
Pterostilbene 16μM R02 exp78	2.52
Phenformin 20μM R05 exp212	2.58
QNZ 0.01μM R08 exp439	2.67
FK-506 30μM R07 exp359	2.68

Gene	Correlation
PPCDC	0.722
DHRSX	0.636
PGM3	0.623
DNLZ	0.616
TRMT61A	0.614
METTL1	0.57
SRD5A3	0.539
PTPMT1	0.538
PARS2	0.535
PTAR1	0.53
FH	0.524
PPA1	0.523
TEN1	0.517
WRB	0.515
WDR83	0.511
RPIA	0.507
TRMT6	0.506
NARS2	0.5
TUBE1	0.493
YARS2	0.486
ELP6	0.483
SELRC1	0.48
LARS2	0.478
RFT1	0.477
GNPNAT1	0.476
EARS2	0.473
C1D	0.473
POLG	0.473
DAP3	0.472
MRPL21	0.471
TMEM242	0.47
LSM10	0.469
PGS1	0.465
C16orf80	0.465
MRPS5	0.463
G6PD	0.459
GEMIN7	0.458
DDX39A	0.458
FKBPL	0.456
PPCS	0.455
TUBD1	0.452
MRPS6	0.448
ALG8	0.446
C15orf41	0.445
TARS2	0.445
KTI12	0.443
POLG2	0.44
GEMIN6	0.439
GEMIN4	0.435
SCO2	0.434
ADAT2	0.432
MSTO1	0.432
HSD17B10	0.427
GATC	0.426
ADAT3	0.425
SLC7A1	0.425
MRE11A	0.423
IBA57	0.423
KDSR	0.418
UGP2	0.417
MRPL23	0.417
ATPAF2	0.416
RBFA	0.414
CXorf56	0.414
ALG6	0.414
TSEN15	0.413
FASTKD5	0.413
URM1	0.412
GET4	0.411
N6AMT1	0.41
ALDH18A1	0.409
BCS1L	0.407
KLF16	0.407
ELP3	0.404
MRPS34	0.404
MTG1	0.403
RARS2	0.402
GEMIN8	0.402
DOLK	0.402
TPK1	0.4

Global Fraction of Cell Lines Where Essential: 80/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	2/28
bone	1/26
breast	5/33
central nervous system	5/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	0/1
gastric	3/16
kidney	2/21
liver	1/20
lung	12/75
lymphocyte	0/16
ovary	0/26
pancreas	5/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	1/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	6/22
urinary tract	7/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 445
Expression level (log2 read counts): 4.59

Expression Distribution